Secondary acute myeloid leukemia in survivors of Hodgkin lymphoma

Vijaya R. Bhatt; Smith Giri; Vivek Verma; Sumit Dahal; Binay K. Shah; Ranjan Pathak; R. Gregory Bociek; Julie M. Vose; James O. Armitage

doi:10.2217/fon-2016-0048

Secondary acute myeloid leukemia in survivors of Hodgkin lymphoma

Vijaya R. Bhatt, Smith Giri, Vivek Verma, Sumit Dahal, Binay K. Shah, Ranjan Pathak, R. Gregory Bociek, Julie M. Vose, James O. Armitage

Research output: Contribution to journal › Article

6 Scopus citations

Abstract

Background: This large population-based study determined the epidemiology and outcomes of secondary acute myeloid leukemia (sAML) developing in Hodgkin lymphoma survivors. Methods: We utilized the Surveillance Epidemiology and End Results (SEER) 9 database to identify 104 cases of sAML. Results: Patients with sAML (median age: 47 years; 82% <60 years) were significantly younger than de novo AML cases (66 years; p < 0.01). sAML had worse overall survival (OS) than de novo AML (p < 0.01). OS was better in younger patients and in more recent years. Conclusion: Older patients with sAML have a dismal OS and should be enrolled in trials of novel therapies. Younger patients have improved OS and hence may benefit from curative intent intensive therapy and allogeneic transplant.

Original language	English (US)
Pages (from-to)	1565-1575
Number of pages	11
Journal	Future Oncology
Volume	12
Issue number	13
DOIs	https://doi.org/10.2217/fon-2016-0048
State	Published - Jul 2016

Keywords

Hodgkin lymphoma
acute myeloid leukemia
survival

ASJC Scopus subject areas

Oncology
Cancer Research

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Bhatt, V. R., Giri, S., Verma, V., Dahal, S., Shah, B. K., Pathak, R., Bociek, R. G., Vose, J. M., & Armitage, J. O. (2016). Secondary acute myeloid leukemia in survivors of Hodgkin lymphoma. Future Oncology, 12(13), 1565-1575. https://doi.org/10.2217/fon-2016-0048

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abstract = "Background: This large population-based study determined the epidemiology and outcomes of secondary acute myeloid leukemia (sAML) developing in Hodgkin lymphoma survivors. Methods: We utilized the Surveillance Epidemiology and End Results (SEER) 9 database to identify 104 cases of sAML. Results: Patients with sAML (median age: 47 years; 82% <60 years) were significantly younger than de novo AML cases (66 years; p < 0.01). sAML had worse overall survival (OS) than de novo AML (p < 0.01). OS was better in younger patients and in more recent years. Conclusion: Older patients with sAML have a dismal OS and should be enrolled in trials of novel therapies. Younger patients have improved OS and hence may benefit from curative intent intensive therapy and allogeneic transplant.",

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author = "Bhatt, {Vijaya R.} and Smith Giri and Vivek Verma and Sumit Dahal and Shah, {Binay K.} and Ranjan Pathak and Bociek, {R. Gregory} and Vose, {Julie M.} and Armitage, {James O.}",

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AU - Bhatt, Vijaya R.

AU - Giri, Smith

AU - Verma, Vivek

AU - Dahal, Sumit

AU - Shah, Binay K.

AU - Pathak, Ranjan

AU - Bociek, R. Gregory

AU - Vose, Julie M.

AU - Armitage, James O.

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KW - acute myeloid leukemia

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