Abstract
Background: This large population-based study determined the epidemiology and outcomes of secondary acute myeloid leukemia (sAML) developing in Hodgkin lymphoma survivors. Methods: We utilized the Surveillance Epidemiology and End Results (SEER) 9 database to identify 104 cases of sAML. Results: Patients with sAML (median age: 47 years; 82% <60 years) were significantly younger than de novo AML cases (66 years; p < 0.01). sAML had worse overall survival (OS) than de novo AML (p < 0.01). OS was better in younger patients and in more recent years. Conclusion: Older patients with sAML have a dismal OS and should be enrolled in trials of novel therapies. Younger patients have improved OS and hence may benefit from curative intent intensive therapy and allogeneic transplant.
Original language | English (US) |
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Pages (from-to) | 1565-1575 |
Number of pages | 11 |
Journal | Future Oncology |
Volume | 12 |
Issue number | 13 |
DOIs | |
State | Published - Jul 2016 |
Keywords
- Hodgkin lymphoma
- acute myeloid leukemia
- survival
ASJC Scopus subject areas
- Oncology
- Cancer Research