Secondary malignancy following radiotherapy for thyroid eye disease

Christopher C. Gillis, Eun Hae Chang, Khalid Al-Kharazi, Tom Pickles

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Aim: To describe the first case of a secondary meningioma in a patient after radiation treatment for thyroid eye disease (TED). Secondarily to identify any additional cases of secondary malignancy resulting from radiotherapy for thyroid eye disease from our institutional experience. Background: Thyroid eye disease (TED) is a self-limiting auto-immune disorder causing expansion of orbital soft tissue from deposition of glycosaminoglycans and collagen, leading to significant cosmetic and functional morbidity. Established management options for TED include: glucocorticosteroids, orbital radiotherapy, and surgical orbital decompression. Two large series on radiotherapy for TED have been reported without any cases of secondary malignancy. Materials and methods: The case of a patient with visual failure, found to have a sphenoid wing meningioma after previous TED radiotherapy is described. We then reviewed 575 patients with at least 3-year follow-up receiving radiotherapy for TED at British Columbia Cancer Agency to identify other possible secondary malignancies. Results: The patient had postoperative improvement in her vision without any identified complications. Three additional cases of hematologic malignancy were identified. The calculated risk in our population of developing a radiation-induced meningioma after TED with at least 3 years of follow-up of is 0.17% (1/575); with hematopoetic malignancies the risk for secondary malignancy is 0.7% (4/575). Conclusions: Our calculated risk for secondary malignancy (0.17%, 0.7%) is similar to the reported theoretical risk published in the literature (0.3-1.2%). There is real risk for the development of a secondary malignancy after radiotherapy treatment of TED and treatment options should include consideration for this potential.

Original languageEnglish (US)
Pages (from-to)156-161
Number of pages6
JournalReports of Practical Oncology and Radiotherapy
Issue number3
StatePublished - May 1 2016


  • Meningioma
  • Radiotherapy
  • Secondary malignancy
  • Thyroid eye disease

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging


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