Secretory carcinoma of the breast limited to the dermis: Cutaneous or breast primary?

Madison Grinnell, Ujwal Yanala, Dominick DiMaio

Research output: Contribution to journalArticlepeer-review


We offer a case of a 22-year-old woman who presented with a painless breast mass. Physical examination of the breast was unrevealing other than a palpable mass in close proximity to the nipple areolar region. No lymphadenopathy was noticed in the axilla or supraclavicular region. Sonographic assessment was performed and the findings were classified as Breast Imaging Reporting and Data System category 4. Because of the proximity of the mass to the skin surface, an excisional biopsy was performed. Final pathology disclosed a 5-mm invasive carcinoma. On pathologic examination, histopathology and immunophenotyping supported the diagnosis of secretory carcinoma; however, whether the origin was from the breast parenchyma or skin tissue was not clearly discernable. Therefore, the patient was scheduled for sentinel lymph node biopsy with plans for axillary dissection if positive. While the overall prognosis for secretory carcinoma is good, with a low chance of metastasis, any ambiguity in breast mass diagnosis should be discussed in a multidisciplinary tumor board and should be treated aggressively particularly in younger patients.

Original languageEnglish (US)
Pages (from-to)1307-1310
Number of pages4
JournalJournal of Cutaneous Pathology
Issue number10
StatePublished - Oct 2021


  • ETV6-NTRK3
  • breast
  • carcinoma
  • secretory
  • skin

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Dermatology


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