Selatogrel: A Novel Subcutaneous P2Y12Inhibitor

Craig J. Beavers, Samuel Aaron Effoe, Paul P. Dobesh

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations


Abstract:The use of a P2Y12inhibitor as a component of dual antiplatelet therapy in patients with an acute coronary syndrome (ACS) is well established. However, the P2Y12inhibitors currently available have pharmacokinetic limitations due to delayed absorption, lack of enteral access for administration with oral formulations, need for intravenous access with cangrelor, or need for metabolization to be ideal in the critical 3-hour window during an ACS. Selatogrel is a novel, potent, reversible, and selective 2-phenylprimdine-4-carboxamide administered subcutaneously under development. Results from preclinical, phase 1, and phase 2 trials have confirmed that the agent provides sustained and reversible P2Y12platelet inhibition with an acceptable safety profile. The most commonly reported adverse effects include minor bleeding and dyspnea. Phase 3 trials are being designed to understand the critical role this agent can play in upstream management of patients with ACS including a more defined understanding of the adverse effect profile, how to transition from this agent to an oral agent, who will be administering, and does this agent allow for a safe and quick transition to coronary artery bypass graft surgery if needed. Should it obtain approval, selatogrel has the potential to provide a unique and advantageous mechanism for P2Y12inhibition.

Original languageEnglish (US)
Pages (from-to)161-167
Number of pages7
JournalJournal of Cardiovascular Pharmacology
Issue number2
StatePublished - Feb 19 2022


  • P2Yinhibitor
  • acute coronary syndrome
  • antiplatelet therapy
  • percutaneous coronary intervention
  • selatogrel

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology


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