Selective deficiency in collagen-induced platelet aggregation during L-asparaginase therapy

Ralph S. Shapiro, Jonathan M. Gerrard, Norma K.C. Ramsay, Mark E. Nesbit, Peter F. Coccia, Steven F. Stoddard, Edward F. Plow, James G. White, William Krivit

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Platelet aggregation studies were performed on 10 pediatric patients with acute lymphoblastic leukemia (ALL) receiving induction therapy with vincristine, prednisone, and L-asparaginase. An isolated abnormality in platelet aggregation in response to collagen was found in all patients during the course of therapy. Platelet aggregation in response to collagen normalized following the discontinuation of L-asparaginase, while patients were still on vincristine and prednisone. In contrast to the abnormal collagen response, platelet aggregation induced by epinephrine, arachidonic acid, adenosine diphosphate (ADP), and thrombin were normal both during and following therapy. In the one patient with a normal platelet count before therapy, aggregation induced by all agents was normal. This selective abnormality in collagen aggregation therefore appears to result from therapy, with the use of L-asparaginase in particular being implicated.

Original languageEnglish (US)
Pages (from-to)207-212
Number of pages6
JournalAmerican Journal of Pediatric Hematology/Oncology
Issue number3
StatePublished - 1980

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology


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