Selective destruction of smaller perfluorocarbon exposed sonicated dextrose albumin microbubbles when using interrupted ultrasound transmission and high acoustic outputs

Thomas Porter, Stooping Li, David Kricsfeld, Seth Cheatham

Research output: Contribution to journalArticle

Abstract

Although intermittent imaging (II) dramatically increases the myocardial contrast produced from an intravenous injection of perfluorocarbon containing microbubbles (PCMB), it is still unknown how different diagnostic ultrasound (DU) transducer frequencies (TF), acoustic outputs (AO), and frame rates (FR) affect the size distribution and concentration (cone) of PCMB over the range of physiologic How rates (FR) and body temperatures (BT). The purpose of this project was to determine how these DU variables affect the size and cone of PCMB MB at physiologic FR in saline or blood at 37 Celsius (C). The size and cone of PCMB were measured following a 0.1 milliliter injection of PCMB proximal to a scanning chamber containing blood or saline flowing at 20,50, or 100 ml/min. Inosonation TF ranged from 2.0 to 7.5 megahertz (MHZ), and AO of 0.1, 0.4, and 1.1 megapascals(MPa). 1 Hz FR was compared to 30 Hz FR and DO DU. Results. At all FR, PCMB size increased when exposed to BT. At 2.0 MHZ, PCMB cone was reduced when using a 30 Hz FR and 1.1 MPa. This destruction did not occur when a lower AO, a higher TF, a 100 cc/min flow rate, or 1 Hz FR. The 1 Hz FR at 2.0 MHZ and 1.1 MPa selectively destroyed smaller MB: (Figure Presented) We conclude mat the greatest destruction of PCMB by DU occurs with low TF, 30 Hz ER and high AO. One Hertz FR (or II) reduces this destruction, but also selectively destroys the smaller MB. II produces greater MC than conventional FR by either preventing destruction of larger MB or by producing a cavitational emission from smaller PCMB.

Original languageEnglish (US)
Pages (from-to)438
Number of pages1
JournalJournal of the American Society of Echocardiography
Volume10
Issue number4
StatePublished - 1997

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Selective destruction of smaller perfluorocarbon exposed sonicated dextrose albumin microbubbles when using interrupted ultrasound transmission and high acoustic outputs'. Together they form a unique fingerprint.

  • Cite this