Selective induction of liver drug-metabolizing enzymes in rats exposed to a 21 ATA He-O2 environment

J. D. Geiger, S. J. Brumleve, J. N. Boelkins, S. S. Parmar

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1 Scopus citations

Abstract

The effects of prolonged exposure to a hyperbaric environment (21 ATA He-O2, 200 ± 30 mm Hg O2, 32.5 ± 1° C) were investigated on the activity of rat liver drug-metabolizing enzyme systems, as monitored by O-dealkylation and N-dealkylation reactions. Continuous exposure of different groups of rats to a hyperbaric environment for 8, 22, 39, 57 or 84 d significantly increased the in vitro activity of drug-metabolizing enzymes in liver preparations obtained from rats subjected to prolonged exposures. The increase in the in vitro O-dealkylation of p-nitro-anisole was selective; and the percent increases were 27, 146, 58, 40, 49 and 44 in liver preparations obtained from rats exposed continuously for 8, 22, 39, 57, 72 or 84 d, respectively. On the other hand, no statistically significant increase was observed in the in vitro activity of rat liver drug-metabolizing enzyme preparations during N-dealkylation of morphine and cocaine.

Original languageEnglish (US)
Pages (from-to)737-740
Number of pages4
JournalAviation Space and Environmental Medicine
Volume48
Issue number8
StatePublished - 1977
Externally publishedYes

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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