Selenoproteins in the endoplasmic reticulum

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

The endoplasmic reticulum (ER) is an organelle which is present in all eukaryotic cells. The ER is a major compartment where protein folding, glycosylation, and disulfide bond formation occur. Selenocysteine containing proteins (selenoproteins) are a subgroup of thiol oxidoreductases. Recent studies demonstrated that 7 of 25 known human selenoproteins, Sep15, SelM, SelT, D2, SelS, SelK, and SelN, reside in the ER. Thus, ER-associated redox processes are dependent on selenoproteins, and consequently, on selenocysteine biosynthesis and overall selenium status of the cell. At the same time, ER selenoproteins include the least characterized human selenoproteins. In this chapter, we summarize recent results on the ER selenoproteome.

Original languageEnglish (US)
Title of host publicationSelenium
Subtitle of host publicationIts Molecular Biology and Role in Human Health
PublisherSpringer New York
Pages221-234
Number of pages14
Volume9781461410256
ISBN (Electronic)9781461410256
ISBN (Print)146141024X, 9781461410249
DOIs
StatePublished - Jun 1 2012

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Fomenko, D. E. (2012). Selenoproteins in the endoplasmic reticulum. In Selenium: Its Molecular Biology and Role in Human Health (Vol. 9781461410256, pp. 221-234). Springer New York. https://doi.org/10.1007/978-1-4614-1025-6_17