Selinexor suppresses downstream effectors of B-cell activation, proliferation and migration in chronic lymphocytic leukemia cells

Y. Zhong; D. El-Gamal; J. A. Dubovsky; K. A. Beckwith; B. K. Harrington; K. E. Williams; V. M. Goettl; S. Jha; X. Mo; J. A. Jones; J. M. Flynn; K. J. Maddocks; L. A. Andritsos; D. McCauley; S. Shacham; M. Kauffman; J. C. Byrd; R. Lapalombella

doi:10.1038/leu.2014.9

Selinexor suppresses downstream effectors of B-cell activation, proliferation and migration in chronic lymphocytic leukemia cells

Y. Zhong, D. El-Gamal, J. A. Dubovsky, K. A. Beckwith, B. K. Harrington, K. E. Williams, V. M. Goettl, S. Jha, X. Mo, J. A. Jones, J. M. Flynn, K. J. Maddocks, L. A. Andritsos, D. McCauley, S. Shacham, M. Kauffman, J. C. Byrd, R. Lapalombella

Research output: Contribution to journal › Letter › peer-review

53 Scopus citations

Original language	English (US)
Pages (from-to)	1158-1163
Number of pages	6
Journal	Leukemia
Volume	28
Issue number	5
DOIs	https://doi.org/10.1038/leu.2014.9
State	Published - May 2014
Externally published	Yes

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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10.1038/leu.2014.9

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Zhong, Y., El-Gamal, D., Dubovsky, J. A., Beckwith, K. A., Harrington, B. K., Williams, K. E., Goettl, V. M., Jha, S., Mo, X., Jones, J. A., Flynn, J. M., Maddocks, K. J., Andritsos, L. A., McCauley, D., Shacham, S., Kauffman, M., Byrd, J. C., & Lapalombella, R. (2014). Selinexor suppresses downstream effectors of B-cell activation, proliferation and migration in chronic lymphocytic leukemia cells. Leukemia, 28(5), 1158-1163. https://doi.org/10.1038/leu.2014.9

Zhong, Y, El-Gamal, D, Dubovsky, JA, Beckwith, KA, Harrington, BK, Williams, KE, Goettl, VM, Jha, S, Mo, X, Jones, JA, Flynn, JM, Maddocks, KJ, Andritsos, LA, McCauley, D, Shacham, S, Kauffman, M, Byrd, JC & Lapalombella, R 2014, 'Selinexor suppresses downstream effectors of B-cell activation, proliferation and migration in chronic lymphocytic leukemia cells', Leukemia, vol. 28, no. 5, pp. 1158-1163. https://doi.org/10.1038/leu.2014.9

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title = "Selinexor suppresses downstream effectors of B-cell activation, proliferation and migration in chronic lymphocytic leukemia cells",

author = "Y. Zhong and D. El-Gamal and Dubovsky, {J. A.} and Beckwith, {K. A.} and Harrington, {B. K.} and Williams, {K. E.} and Goettl, {V. M.} and S. Jha and X. Mo and Jones, {J. A.} and Flynn, {J. M.} and Maddocks, {K. J.} and Andritsos, {L. A.} and D. McCauley and S. Shacham and M. Kauffman and Byrd, {J. C.} and R. Lapalombella",

note = "Funding Information: We are grateful to the patients who provided blood for the above-mentioned studies, research support from The Leukemia and Lymphoma Society in the form of a translational grant and Specialized Center of Research, and the National Cancer Institute (P50 CA140158 and 1K12 CA133250). We are grateful to Alan Flechtner and the Comparative Pathology and Mouse Phenotyping Shared Resource at the Ohio State University for their technical support Funding Information: We thank Drs Apollina Goel and Jeanine Schibler for providing expert assistance. This work was supported by the National Cancer Institute grants R01CA115399 (to GT), R01CA152105 (to FZ), R01CA151354 (to SJ) and R21CA143887 (to FZ), the MMRF Senior (to FZ, 2008 and 2010), the leukemia lymphoma society TRP (to FZ, 2010 and 2011), institutional start-up funds from the Department of Internal Medicine, Carver School of Medicine, University of Iowa (to FZ and GT), and the National Natural Science Foundation of China, P. R. China (No. 81228016 to FZ and JS).",

year = "2014",

month = may,

doi = "10.1038/leu.2014.9",

language = "English (US)",

volume = "28",

pages = "1158--1163",

journal = "Leukemia",

issn = "0887-6924",

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T1 - Selinexor suppresses downstream effectors of B-cell activation, proliferation and migration in chronic lymphocytic leukemia cells

AU - Zhong, Y.

AU - El-Gamal, D.

AU - Dubovsky, J. A.

AU - Beckwith, K. A.

AU - Harrington, B. K.

AU - Williams, K. E.

AU - Goettl, V. M.

AU - Jha, S.

AU - Mo, X.

AU - Jones, J. A.

AU - Flynn, J. M.

AU - Maddocks, K. J.

AU - Andritsos, L. A.

AU - McCauley, D.

AU - Shacham, S.

AU - Kauffman, M.

AU - Byrd, J. C.

AU - Lapalombella, R.

N1 - Funding Information: We are grateful to the patients who provided blood for the above-mentioned studies, research support from The Leukemia and Lymphoma Society in the form of a translational grant and Specialized Center of Research, and the National Cancer Institute (P50 CA140158 and 1K12 CA133250). We are grateful to Alan Flechtner and the Comparative Pathology and Mouse Phenotyping Shared Resource at the Ohio State University for their technical support Funding Information: We thank Drs Apollina Goel and Jeanine Schibler for providing expert assistance. This work was supported by the National Cancer Institute grants R01CA115399 (to GT), R01CA152105 (to FZ), R01CA151354 (to SJ) and R21CA143887 (to FZ), the MMRF Senior (to FZ, 2008 and 2010), the leukemia lymphoma society TRP (to FZ, 2010 and 2011), institutional start-up funds from the Department of Internal Medicine, Carver School of Medicine, University of Iowa (to FZ and GT), and the National Natural Science Foundation of China, P. R. China (No. 81228016 to FZ and JS).

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Selinexor suppresses downstream effectors of B-cell activation, proliferation and migration in chronic lymphocytic leukemia cells

ASJC Scopus subject areas

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