Sending out an SOS: Mitochondria as a signaling hub

Iryna Bohovych, Oleh Khalimonchuk

Research output: Contribution to journalReview article

31 Scopus citations

Abstract

Normal cellular physiology is critically dependent on numerous mitochondrial activities including energy conversion, cofactor and precursor metabolite synthesis, and regulation of ion and redox homeostasis. Advances in mitochondrial research during the last two decades provide solid evidence that these organelles are deeply integrated with the rest of the cell and multiple mechanisms are in place to monitor and communicate functional states of mitochondria. In many cases, however, the exact molecular nature of various mitochondria-to-cell communication pathways is only beginning to emerge. Here, we review various signals emitted by distressed or dysfunctional mitochondria and the stress-responsive pathways activated in response to these signals in order to restore mitochondrial function and promote cellular survival.

Original languageEnglish (US)
Article number109
JournalFrontiers in Cell and Developmental Biology
Volume4
Issue numberOCT
DOIs
StatePublished - Oct 13 2016

Keywords

  • Metabolites
  • Mitochondria
  • Mitochondrial stress
  • Reactive oxygen species
  • Retrograde signaling

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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