Sensitive determination of RDX, nitroso-RDX metabolites, and other munitions in ground water by solid-phase extraction and isotope dilution liquid chromatography-atmospheric pressure chemical ionization mass spectrometry

D. A. Cassada, S. J. Monson, D. D. Snow, R. F. Spalding

Research output: Contribution to journalArticlepeer-review

65 Scopus citations

Abstract

Recent improvements in the LC-MS interface have increased the sensitivity and selectivity of this instrument in the analysis of polar and thermally-labile aqueous constituents. Determination of RDX, nitroso-RDX metabolites, and other munitions was enhanced using LC-MS with solid-phase extraction, 15N3-RDX internal standard, and electrospray ionization (ESI) in negative ion mode. ESI produced a five-fold increase in detector response over atmospheric pressure chemical ionization (APCI) for the nitramine compounds, while the more energetic APCI produced more than twenty times the ESI response for nitroaromatics. Method detection limits in ESI for nitramines varied from 0.03 μgl-1 for MNX to 0.05 μgl-1 for RDX. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)87-95
Number of pages9
JournalJournal of Chromatography A
Volume844
Issue number1-2
DOIs
StatePublished - Jun 4 1999

Keywords

  • 1,3,5-Trinitro-1,3,5-triazacyclohexane
  • Explosives
  • Nitramines
  • Nitroaromatics
  • RDX

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry

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