Abstract
d-Amphetamine transiently stimulates the expression of the immediate-early response gene, c-fos, in rat striatal cell nuclei. d-Amphetamine (2.5 mg/kg i.p.) induced a significantly greater expression of Fos-like immunoreactivity in striatum of rats treated three days previously with d-amphetamine compared to rats treated three days previously with saline. This increase in the expression of Fos-like immunoreactivity in rat striatum was characterized by a significantly greater number of immunoreactive nuclei and a significant increase in the intensity of the immunoreactivity. This sensitization of c-fos expression following a repeated administration of d-amphetamine indicates an increased activation of post-synaptic elements in rat striatum.
Original language | English (US) |
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Pages (from-to) | 125-128 |
Number of pages | 4 |
Journal | Brain Research |
Volume | 603 |
Issue number | 1 |
DOIs | |
State | Published - Feb 12 1993 |
Externally published | Yes |
Keywords
- Addiction
- Cell counting
- Immediate-early response gene
- Immunocytochemistry
- Oncoprotein
- Stimulant
ASJC Scopus subject areas
- Neuroscience(all)
- Molecular Biology
- Clinical Neurology
- Developmental Biology