Sensitization of c-fos expression in rat striatum following multiple challenges with d-amphetamine

Andrew B. Norman; Sunny Y. Lu; Jennifer M. Klug; Robert B. Norgren

doi:10.1016/0006-8993(93)91308-F

Sensitization of c-fos expression in rat striatum following multiple challenges with d-amphetamine

Andrew B. Norman, Sunny Y. Lu, Jennifer M. Klug, Robert B. Norgren

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

d-Amphetamine transiently stimulates the expression of the immediate-early response gene, c-fos, in rat striatal cell nuclei. d-Amphetamine (2.5 mg/kg i.p.) induced a significantly greater expression of Fos-like immunoreactivity in striatum of rats treated three days previously with d-amphetamine compared to rats treated three days previously with saline. This increase in the expression of Fos-like immunoreactivity in rat striatum was characterized by a significantly greater number of immunoreactive nuclei and a significant increase in the intensity of the immunoreactivity. This sensitization of c-fos expression following a repeated administration of d-amphetamine indicates an increased activation of post-synaptic elements in rat striatum.

Original language	English (US)
Pages (from-to)	125-128
Number of pages	4
Journal	Brain Research
Volume	603
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(93)91308-F
State	Published - Feb 12 1993
Externally published	Yes

Keywords

Addiction
Cell counting
Immediate-early response gene
Immunocytochemistry
Oncoprotein
Stimulant

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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title = "Sensitization of c-fos expression in rat striatum following multiple challenges with d-amphetamine",

abstract = "d-Amphetamine transiently stimulates the expression of the immediate-early response gene, c-fos, in rat striatal cell nuclei. d-Amphetamine (2.5 mg/kg i.p.) induced a significantly greater expression of Fos-like immunoreactivity in striatum of rats treated three days previously with d-amphetamine compared to rats treated three days previously with saline. This increase in the expression of Fos-like immunoreactivity in rat striatum was characterized by a significantly greater number of immunoreactive nuclei and a significant increase in the intensity of the immunoreactivity. This sensitization of c-fos expression following a repeated administration of d-amphetamine indicates an increased activation of post-synaptic elements in rat striatum.",

keywords = "Addiction, Cell counting, Immediate-early response gene, Immunocytochemistry, Oncoprotein, Stimulant",

author = "Norman, {Andrew B.} and Lu, {Sunny Y.} and Klug, {Jennifer M.} and Norgren, {Robert B.}",

note = "Funding Information: This work was supported by MH45253 from ADAMHA. We would like to thank Stephen McKeehan for excellent technical assistance and Mel Fariello for manuscript preparation.",

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AU - Norman, Andrew B.

AU - Lu, Sunny Y.

AU - Klug, Jennifer M.

AU - Norgren, Robert B.

N1 - Funding Information: This work was supported by MH45253 from ADAMHA. We would like to thank Stephen McKeehan for excellent technical assistance and Mel Fariello for manuscript preparation.

PY - 1993/2/12

Y1 - 1993/2/12

N2 - d-Amphetamine transiently stimulates the expression of the immediate-early response gene, c-fos, in rat striatal cell nuclei. d-Amphetamine (2.5 mg/kg i.p.) induced a significantly greater expression of Fos-like immunoreactivity in striatum of rats treated three days previously with d-amphetamine compared to rats treated three days previously with saline. This increase in the expression of Fos-like immunoreactivity in rat striatum was characterized by a significantly greater number of immunoreactive nuclei and a significant increase in the intensity of the immunoreactivity. This sensitization of c-fos expression following a repeated administration of d-amphetamine indicates an increased activation of post-synaptic elements in rat striatum.

AB - d-Amphetamine transiently stimulates the expression of the immediate-early response gene, c-fos, in rat striatal cell nuclei. d-Amphetamine (2.5 mg/kg i.p.) induced a significantly greater expression of Fos-like immunoreactivity in striatum of rats treated three days previously with d-amphetamine compared to rats treated three days previously with saline. This increase in the expression of Fos-like immunoreactivity in rat striatum was characterized by a significantly greater number of immunoreactive nuclei and a significant increase in the intensity of the immunoreactivity. This sensitization of c-fos expression following a repeated administration of d-amphetamine indicates an increased activation of post-synaptic elements in rat striatum.

KW - Addiction

KW - Cell counting

KW - Immediate-early response gene

KW - Immunocytochemistry

KW - Oncoprotein

KW - Stimulant

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Sensitization of c-fos expression in rat striatum following multiple challenges with d-amphetamine

Abstract

Keywords

ASJC Scopus subject areas

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