TY - JOUR
T1 - Sensorineural hearing loss caused by mitochondrial dna mutations
T2 - Special reference to the A1555G mutation
AU - Usami, Shin Ichi
AU - Abe, Satoko
AU - Shinkawa, Hideichi
AU - Kimberling, William J.
N1 - Funding Information:
The authors thank the participating families. This study was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan (S.U. and H.S.), a Health Sciences Research Grant from the Ministry of Health and Welfare of Japan (S.U.), and by NIH-NIDCD PO1 DC01813 (W.J.K.).
PY - 1998
Y1 - 1998
N2 - Mutations in mitochondrial DNA, which are maternally inherited, have been thought to be one of the causes of sensorineural hearing loss. Two mitochondrial mutational sites (A1555G, A7445G) have been reported to be responsible for non-syndromic hearing impairments. The A 1555G mutation causes increased susceptibility to aminoglycoside antibiotic-induced hearing loss as well as non-syndromic sensorineural hearing loss. Our wide screening study showed that there may be a great number of subjects within the Japanese population who have the A1555G mutation. Recent reports suggest that high- risk populations may exist throughout the world. The aminoglycoside-induced hearing loss associated with a mitochondrial mutation is commonly bilateral, symmetric, high frequency involved, and is sometimes associated with progressive sensorineural hearing loss.
AB - Mutations in mitochondrial DNA, which are maternally inherited, have been thought to be one of the causes of sensorineural hearing loss. Two mitochondrial mutational sites (A1555G, A7445G) have been reported to be responsible for non-syndromic hearing impairments. The A 1555G mutation causes increased susceptibility to aminoglycoside antibiotic-induced hearing loss as well as non-syndromic sensorineural hearing loss. Our wide screening study showed that there may be a great number of subjects within the Japanese population who have the A1555G mutation. Recent reports suggest that high- risk populations may exist throughout the world. The aminoglycoside-induced hearing loss associated with a mitochondrial mutation is commonly bilateral, symmetric, high frequency involved, and is sometimes associated with progressive sensorineural hearing loss.
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U2 - 10.1016/S0021-9924(98)00014-8
DO - 10.1016/S0021-9924(98)00014-8
M3 - Article
C2 - 9777488
AN - SCOPUS:0032168489
SN - 0021-9924
VL - 31
SP - 423
EP - 435
JO - Journal of Communication Disorders
JF - Journal of Communication Disorders
IS - 5
ER -