Sequence of a cDNA encoding the p53 protein in Rhesus monkey (Macaca mulatta)

H. David Kay; Charles P. Mountjoy; Guanqing Wu; Kurtis G. Cornish; Larry J. Smith

doi:10.1016/0378-1119(94)90812-5

Sequence of a cDNA encoding the p53 protein in Rhesus monkey (Macaca mulatta)

H. David Kay, Charles P. Mountjoy, Guanqing Wu, Kurtis G. Cornish, Larry J. Smith

Cellular & Integrative Physiology

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

A 2184-nucleotide (nt) sequence of the p53 gene in Rhesus monkey (Macaca mulatta) was determined in order to facilitate the use of the Rhesus as an animal model in the testing of novel antisense oligodeoxyribonucleotides for a variety of human cancers, including acute myelogenous leukemia (AML). Within overlapping regions, we found greater than 95% identity between the Rhesus and human p53 sequences, and greater than 98% identity between Rhesus and African green monkey p53 sequences. The deduced amino acid (aa) sequence of the p53 protein is highly conserved between human and Rhesus monkey, with only 18 minor differences in 393 aa.

Original language	English (US)
Pages (from-to)	223-226
Number of pages	4
Journal	Gene
Volume	138
Issue number	1-2
DOIs	https://doi.org/10.1016/0378-1119(94)90812-5
State	Published - Jan 28 1994

Keywords

AML
PCR
animal model
antisense
cancer
leukemia
therapeutics

ASJC Scopus subject areas

Genetics

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10.1016/0378-1119(94)90812-5

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title = "Sequence of a cDNA encoding the p53 protein in Rhesus monkey (Macaca mulatta)",

abstract = "A 2184-nucleotide (nt) sequence of the p53 gene in Rhesus monkey (Macaca mulatta) was determined in order to facilitate the use of the Rhesus as an animal model in the testing of novel antisense oligodeoxyribonucleotides for a variety of human cancers, including acute myelogenous leukemia (AML). Within overlapping regions, we found greater than 95% identity between the Rhesus and human p53 sequences, and greater than 98% identity between Rhesus and African green monkey p53 sequences. The deduced amino acid (aa) sequence of the p53 protein is highly conserved between human and Rhesus monkey, with only 18 minor differences in 393 aa.",

keywords = "AML, PCR, animal model, antisense, cancer, leukemia, therapeutics",

author = "{David Kay}, H. and Mountjoy, {Charles P.} and Guanqing Wu and Cornish, {Kurtis G.} and Smith, {Larry J.}",

note = "Funding Information: This work was supported in part by Cancer Center Support Grant No. CA36727 from the National Cancer Institute to the Eppley Institute for Cancer Research,a nd by Department of Internal Medicine research funds.",

year = "1994",

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doi = "10.1016/0378-1119(94)90812-5",

language = "English (US)",

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pages = "223--226",

journal = "Gene",

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T1 - Sequence of a cDNA encoding the p53 protein in Rhesus monkey (Macaca mulatta)

AU - David Kay, H.

AU - Mountjoy, Charles P.

AU - Wu, Guanqing

AU - Cornish, Kurtis G.

AU - Smith, Larry J.

N1 - Funding Information: This work was supported in part by Cancer Center Support Grant No. CA36727 from the National Cancer Institute to the Eppley Institute for Cancer Research,a nd by Department of Internal Medicine research funds.

PY - 1994/1/28

Y1 - 1994/1/28

N2 - A 2184-nucleotide (nt) sequence of the p53 gene in Rhesus monkey (Macaca mulatta) was determined in order to facilitate the use of the Rhesus as an animal model in the testing of novel antisense oligodeoxyribonucleotides for a variety of human cancers, including acute myelogenous leukemia (AML). Within overlapping regions, we found greater than 95% identity between the Rhesus and human p53 sequences, and greater than 98% identity between Rhesus and African green monkey p53 sequences. The deduced amino acid (aa) sequence of the p53 protein is highly conserved between human and Rhesus monkey, with only 18 minor differences in 393 aa.

AB - A 2184-nucleotide (nt) sequence of the p53 gene in Rhesus monkey (Macaca mulatta) was determined in order to facilitate the use of the Rhesus as an animal model in the testing of novel antisense oligodeoxyribonucleotides for a variety of human cancers, including acute myelogenous leukemia (AML). Within overlapping regions, we found greater than 95% identity between the Rhesus and human p53 sequences, and greater than 98% identity between Rhesus and African green monkey p53 sequences. The deduced amino acid (aa) sequence of the p53 protein is highly conserved between human and Rhesus monkey, with only 18 minor differences in 393 aa.

KW - AML

KW - PCR

KW - animal model

KW - antisense

KW - cancer

KW - leukemia

KW - therapeutics

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DO - 10.1016/0378-1119(94)90812-5

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AN - SCOPUS:0028198197

SN - 0378-1119

VL - 138

SP - 223

EP - 226

JO - Gene

JF - Gene

IS - 1-2

ER -

Sequence of a cDNA encoding the p53 protein in Rhesus monkey (Macaca mulatta)

Abstract

Keywords

ASJC Scopus subject areas

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