Sequence of a cDNA encoding the p53 protein in Rhesus monkey (Macaca mulatta)

H. David Kay, Charles P. Mountjoy, Guanqing Wu, Kurtis G. Cornish, Larry J. Smith

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

A 2184-nucleotide (nt) sequence of the p53 gene in Rhesus monkey (Macaca mulatta) was determined in order to facilitate the use of the Rhesus as an animal model in the testing of novel antisense oligodeoxyribonucleotides for a variety of human cancers, including acute myelogenous leukemia (AML). Within overlapping regions, we found greater than 95% identity between the Rhesus and human p53 sequences, and greater than 98% identity between Rhesus and African green monkey p53 sequences. The deduced amino acid (aa) sequence of the p53 protein is highly conserved between human and Rhesus monkey, with only 18 minor differences in 393 aa.

Original languageEnglish (US)
Pages (from-to)223-226
Number of pages4
JournalGene
Volume138
Issue number1-2
DOIs
StatePublished - Jan 28 1994

Keywords

  • AML
  • PCR
  • animal model
  • antisense
  • cancer
  • leukemia
  • therapeutics

ASJC Scopus subject areas

  • Genetics

Fingerprint Dive into the research topics of 'Sequence of a cDNA encoding the p53 protein in Rhesus monkey (Macaca mulatta)'. Together they form a unique fingerprint.

Cite this