Sequence of a novel simian immunodeficiency virus from a wild-caught African mandrill

Hajime Tsujimoto, Akira Hasegawa, Noboru Maki, Masashi Fukasawa, Tomoyuki Miura, Stephan Speidel, Robert W. Cooper, Etsuko N. Moriyama, Takashi Gojobori, Masanori Hayami

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Abstract

SINCE the isolation of an HIV-2-related virus from captive macaques (SIVMAC), the origin of human immunodeficiency viruses, a much debated subject, has been attributed to monkeys. The sequence of SIVAGM, which is derived from a naturally infected African green monkey, shows equal relatedness to HIV-1 and HIV-2, suggesting that the derivation of these viruses from SIVAGM is unlikely. Recent sequence analysis of SIV from a captive sooty mangabey (SIVSM), however, shows its close relatedness to HIV-2 and SIVMAC, indicating a possible origin of HIV-2 and SIVMAC from SIVSM (refs 4, 7, 9). We report here the sequence of a novel simian lentivirus, SIVMND, isolated from a wild-caught mandrill in Africa. It is distinct from the three other main groups, HIV-1, HIV-2/SIVMAC/SIVSM and SIVAGM, and therefore represents a fourth main group of primate lentiviruses. Phylogenetic analysis indicates that these four main virus groups might have diverged from a common ancestor at about the same time, long before the spread of AIDS in humans.

Original languageEnglish (US)
Pages (from-to)539-541
Number of pages3
JournalNature
Volume341
Issue number6242
DOIs
StatePublished - Jan 1 1989

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    Tsujimoto, H., Hasegawa, A., Maki, N., Fukasawa, M., Miura, T., Speidel, S., Cooper, R. W., Moriyama, E. N., Gojobori, T., & Hayami, M. (1989). Sequence of a novel simian immunodeficiency virus from a wild-caught African mandrill. Nature, 341(6242), 539-541. https://doi.org/10.1038/341539a0