Serine/threonine phosphatases in the DNA damage response and cancer

A. Peng; J. L. Maller

doi:10.1038/onc.2010.371

Serine/threonine phosphatases in the DNA damage response and cancer

A. Peng, J. L. Maller

Research output: Contribution to journal › Review article › peer-review

59 Scopus citations

Abstract

The cellular response to DNA damage is a crucial surveillance mechanism that maintains genomic integrity and prevents cancer progression. Previous studies identified multiple Ser/Thr protein kinases that have pivotal roles in the activation of this response. It is interesting that a growing body of evidence suggests that these kinases and their substrates are under tight modulation by numerous Ser/Thr phosphatases. In this study, we review recent reports that reveal new functions and regulation of these phosphatases. Similar to the kinases in this pathway, phosphatases may also be intimately involved in cancer progression and present valuable targets for cancer therapy.

Original language	English (US)
Pages (from-to)	5977-5988
Number of pages	12
Journal	Oncogene
Volume	29
Issue number	45
DOIs	https://doi.org/10.1038/onc.2010.371
State	Published - Nov 11 2010

Keywords

DNA damage
cancer
checkpoint
protein phosphatase

ASJC Scopus subject areas

Molecular Biology
Genetics
Cancer Research

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10.1038/onc.2010.371

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abstract = "The cellular response to DNA damage is a crucial surveillance mechanism that maintains genomic integrity and prevents cancer progression. Previous studies identified multiple Ser/Thr protein kinases that have pivotal roles in the activation of this response. It is interesting that a growing body of evidence suggests that these kinases and their substrates are under tight modulation by numerous Ser/Thr phosphatases. In this study, we review recent reports that reveal new functions and regulation of these phosphatases. Similar to the kinases in this pathway, phosphatases may also be intimately involved in cancer progression and present valuable targets for cancer therapy.",

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AB - The cellular response to DNA damage is a crucial surveillance mechanism that maintains genomic integrity and prevents cancer progression. Previous studies identified multiple Ser/Thr protein kinases that have pivotal roles in the activation of this response. It is interesting that a growing body of evidence suggests that these kinases and their substrates are under tight modulation by numerous Ser/Thr phosphatases. In this study, we review recent reports that reveal new functions and regulation of these phosphatases. Similar to the kinases in this pathway, phosphatases may also be intimately involved in cancer progression and present valuable targets for cancer therapy.

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KW - checkpoint

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Serine/threonine phosphatases in the DNA damage response and cancer

Abstract

Keywords

ASJC Scopus subject areas

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