Serological evidence of Burkholderia pseudomallei infection in U.S. marines who trained in Australia from 2012–2014: A retrospective analysis of archived samples

Kevin L. Schully, Mary N. Burtnick, Matthew G. Bell, Ammarah Spall, Mark Mayo, Vanessa Rigas, Alyssa A. Chan, Kathleen Yu, Danielle V. Clark, Ryan C. Maves, Bart J. Currie, Paul J. Brett, James V. Lawler

Research output: Contribution to journalArticlepeer-review

Abstract

Infection with the gram-negative bacterium Burkholderia pseudomallei can result in a life-threatening disease known as melioidosis. Historically, meli-oidosis was a common infection in military forces serving in Southeast Asia, and it has the potential to have a serious impact on force health readiness. With the U.S. Department of Defense’s increasing strategic and operational focus across the Pacific Theater, melioidosis is an increasingly important issue from a force health protection perspective. U.S. Marines deploy annu-ally to Darwin, Australia, a “hyperendemic” region for B. pseudomallei, to engage in training exercises. In an effort to assess the risk of B. pseudomallei infection to service personnel in Australia, 341 paired samples, represent-ing pre-and post-deployment samples of Marines who trained in Austra-lia, were analyzed for antibodies against B. pseudomallei antigens. Serological evidence of possible deployment-related infection with B. pseudomallei was found in 13 Marines. Future prospective studies are required to further char-acterize the risk to service members deployed to melioidosis endemic areas.

Original languageEnglish (US)
Pages (from-to)8-17
Number of pages10
JournalMedical Surveillance Monthly Report
Volume26
Issue number7
StatePublished - Jul 2019

ASJC Scopus subject areas

  • Medicine(all)

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