TY - JOUR
T1 - Seroprevalence of human herpesvirus 8 among Zambian women of childbearing age without Kaposi's sarcoma (KS) and mother-child pairs with KS
AU - He, Jun
AU - Bhat, Ganapati
AU - Kankasa, Chipepo
AU - Chintu, Chifumbe
AU - Mitchell, Charles
AU - Duan, Wenjing
AU - Wood, Charles
N1 - Funding Information:
Received 13 April 1998; revised 24 July 1998. Informed consent was obtained from study participants or their parents, and the study was approved by the University Teaching Hospital Research Ethics Committee. Grant support: NIH (AI-30356, CA-76958, CA-75903 to C.W.; TW-00015 to C.M.); Cancer and Smoking Diseases Research Program, Nebraska (98-49 to C.W.). Reprints or correspondence: Dr. Charles Wood, School of Biological Sciences, University of Nebraska, Lincoln, NE 68588-0666 ([email protected]).
PY - 1998
Y1 - 1998
N2 - The seroprevalence of human herpesvirus 8 (HHV-8) among a group of Zambian women of reproductive age and among mother-child pairs in which either one of them has Kaposi's sarcoma (KS) was determined. A cross- sectional group of 378 pregnant women was randomly recruited into the study, and 183 (48.4%) had HHV-8 antibodies. Among the human immunodeficiency virus (HIV)-1-infected women, 51.1% were HHV-8-seropositive, whereas of HIV-1- negative women, 47.3% were HHV-8-seropositive. In addition, 21 women index patients with KS and 5 young children index patients with KS were studied. All children with KS had mothers who were HHV-8-seropositive, while not all children whose mothers had KS were infected with HHV-8. Our study suggests that there is a high HHV-8 seroprevalence among Zambian women, and the rate is almost the same in HIV-1-positive and -negative women. This high seroprevalence may be a contributing factor toward the increased frequency of KS in this population.
AB - The seroprevalence of human herpesvirus 8 (HHV-8) among a group of Zambian women of reproductive age and among mother-child pairs in which either one of them has Kaposi's sarcoma (KS) was determined. A cross- sectional group of 378 pregnant women was randomly recruited into the study, and 183 (48.4%) had HHV-8 antibodies. Among the human immunodeficiency virus (HIV)-1-infected women, 51.1% were HHV-8-seropositive, whereas of HIV-1- negative women, 47.3% were HHV-8-seropositive. In addition, 21 women index patients with KS and 5 young children index patients with KS were studied. All children with KS had mothers who were HHV-8-seropositive, while not all children whose mothers had KS were infected with HHV-8. Our study suggests that there is a high HHV-8 seroprevalence among Zambian women, and the rate is almost the same in HIV-1-positive and -negative women. This high seroprevalence may be a contributing factor toward the increased frequency of KS in this population.
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U2 - 10.1086/314512
DO - 10.1086/314512
M3 - Article
C2 - 9815235
AN - SCOPUS:0031766131
SN - 0022-1899
VL - 178
SP - 1787
EP - 1790
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 6
ER -