Seroprevalence of human herpesvirus 8 and its impact on the hemoglobin level in patients of end stage of renal diseases

Qiwen Fang, Xiaoyi Wang, Zhenqiu Liu, Ming Zhu, Min Ding, Veenu Minhas, Charles Wood, Tiejun Zhang

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


The incidence of Kaposi's sarcoma (KS) is increasing among renal transplant recipients. Patients with end-stage renal disease (ESRD) are immunocompromised and are candidates for renal transplantation, but HHV8 seroprevalence in ESRD patients has not been well documented. A cross-sectional study of 286 ESRD patients and 281 matched subjects without kidney disease was conducted at the First People's Hospital of Huzhou, Zhejiang province to explore the epidemiologic features of HHV8 among ESRD patients in China. Blood samples were collected and HHV8 antibodies and serologic indices were measured. The seroprevalence of HHV8 was 15.3% for ESRD patients and 8.9% for the comparison group. A significant difference in the geometric mean titer (GMT) of the HHV8 antibodies was detected between ESRD patients and the comparison group (617.1 vs 291.7; P = 0.042). The average level of hemoglobin was 11.56 ± 1.78 g/dL for the ESRD group and 13.73 ± 1.42 g/dL for the comparison group, (P > 0.05). Multiple linear regression revealed a negative association between HHV8 infection and plasma hemoglobin concentration (β = −0.682, P = 0.036). We found a higher HHV8 prevalence and a higher level of HHV8 antibody GMT in ESRD patients than the comparison group, which indicate a high risk of posttransplantation KS.

Original languageEnglish (US)
Pages (from-to)338-343
Number of pages6
JournalJournal of Medical Virology
Issue number2
StatePublished - Feb 2018


  • end-stage renal disease
  • human herpesvirus 8
  • prevalence

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology


Dive into the research topics of 'Seroprevalence of human herpesvirus 8 and its impact on the hemoglobin level in patients of end stage of renal diseases'. Together they form a unique fingerprint.

Cite this