Abstract
The hypothalamic suprachiasmatic nucleus (SCN) is a circadian oscillator that functions as a biological clock. SCN circadian activity is modulated by serotonergic input arising from the median raphe nucleus. The effects of this monoamine neurotransmitter in the SCN are mediated via several serotonin receptor subtypes that modify the SCN response to light and/or the phase of the SCN oscillation. Disruptions of circadian rhythms are associated with mood disorders and serotonin has been implicated in their pathophysiology. Pharmacological treatments for affective disorders that produce their effects through the serotonergic system can affect the SCN and the regulation of circadian rhythms.
Original language | English (US) |
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Title of host publication | Encyclopedia of Neuroscience |
Publisher | Elsevier Ltd |
Pages | 723-730 |
Number of pages | 8 |
ISBN (Print) | 9780080450469 |
DOIs | |
State | Published - 2009 |
Externally published | Yes |
Keywords
- Biological clock
- Chronopharmacology
- Circadian rhythm
- Mood disorders
- Retinohypothalamic tract
- Seasonal affective disorder (SAD)
- Selective serotonin reuptake inhibitor (SSRI)
- Serotonin (5-HT)
- Serotonin receptors
- Suprachiasmatic nucleus
ASJC Scopus subject areas
- General Neuroscience