Serotonin Syndrome Precipitated by Fentanyl During Procedural Sedation

Ron Kirschner, J. Ward Donovan

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


Fentanyl is frequently used for analgesia during emergency procedures. We present the cases of 2 patients who developed agitation and delirium after intravenous fentanyl administration. These patients were chronically taking selective serotonin reuptake inhibitors (SSRIs). Both developed neuromuscular examinations consistent with serotonin syndrome, a diagnosis that must be established on the basis of clinical criteria. Although they required aggressive supportive care, including mechanical ventilation, both patients made a full recovery. Use of fentanyl for procedural sedation may precipitate serotonin syndrome in patients taking SSRIs or other serotonergic drugs.

Original languageEnglish (US)
Pages (from-to)477-480
Number of pages4
JournalJournal of Emergency Medicine
Issue number4
StatePublished - May 2010
Externally publishedYes


  • drug interaction
  • fentanyl
  • procedural sedation
  • serotonin syndrome
  • serotonin toxicity

ASJC Scopus subject areas

  • Emergency Medicine


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