Serum amyloid A1 (SAA1) protein in human colostrum

George H. Sack, Natasha Zachara, Nadine Rosenblum, C. Conover Talbot, Simion Kreimer, Robert Cole, Thomas L. McDonald

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Proteins of the serum amyloid A (SAA) family have been remarkably conserved in evolution. Their biologic function(s) are not fully defined but they are likely to be a part of primordial host defense. We have detected a ∼ 12-kDa protein reacting with antibodies against serum amyloid A (SAA) in human colostrum by western blotting. Mass spectrometry identified the reactive species as SAA1, previously identified as a prominent member of the acute-phase response in serum. Our finding SAA1 in human colostrum contrasts with bovine, caprine and ovine colostrum where a species corresponding to putative SAA3 is uniformly present. SAA1 protein in human colostrum presumably contributes to neonatal protection.

Original languageEnglish (US)
Pages (from-to)435-441
Number of pages7
JournalFEBS Open Bio
Volume8
Issue number3
DOIs
StatePublished - Mar 2018

Keywords

  • acute-phase
  • amyloid
  • colostrum
  • serum amyloid A

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Sack, G. H., Zachara, N., Rosenblum, N., Talbot, C. C., Kreimer, S., Cole, R., & McDonald, T. L. (2018). Serum amyloid A1 (SAA1) protein in human colostrum. FEBS Open Bio, 8(3), 435-441. https://doi.org/10.1002/2211-5463.12383