@article{8c3dccf24e0d48959046689e1db0ae8b,
title = "Serum amyloid A1 (SAA1) protein in human colostrum",
abstract = "Proteins of the serum amyloid A (SAA) family have been remarkably conserved in evolution. Their biologic function(s) are not fully defined but they are likely to be a part of primordial host defense. We have detected a ∼ 12-kDa protein reacting with antibodies against serum amyloid A (SAA) in human colostrum by western blotting. Mass spectrometry identified the reactive species as SAA1, previously identified as a prominent member of the acute-phase response in serum. Our finding SAA1 in human colostrum contrasts with bovine, caprine and ovine colostrum where a species corresponding to putative SAA3 is uniformly present. SAA1 protein in human colostrum presumably contributes to neonatal protection.",
keywords = "acute-phase, amyloid, colostrum, serum amyloid A",
author = "Sack, {George H.} and Natasha Zachara and Nadine Rosenblum and Talbot, {C. Conover} and Simion Kreimer and Robert Cole and McDonald, {Thomas L.}",
note = "Funding Information: Support for these studies was provided by generous gifts to GS from: Stuart Bainum, Mary Nell and George A. Berry, Ethelbert Cooper, Gloria and Edward Felsenthal, Ruth Frey, Shirley Griffin, Ruth and George Harms, Yancey and David Hillegas, Dia-ntha Johnson, Bassem Kudsi, Steven Lazinsky, Judy Lewent and Mark Shapiro, Terrence O{\textquoteright}Donnell, Jay Ripley, Israel Vainboim, The Foundation for Greater Good, the Health Network Foundation, and The Met Life Foundation. NZ was supported by HL107153. RC was supported by the Johns Hopkins Institute for Clinical and Translational Research/Translational Science Cores NIH UL1 TR001079. Publisher Copyright: {\textcopyright} 2018 The Authors. Published by FEBS Press and John Wiley & Sons Ltd.",
year = "2018",
month = mar,
doi = "10.1002/2211-5463.12383",
language = "English (US)",
volume = "8",
pages = "435--441",
journal = "FEBS Open Bio",
issn = "2211-5463",
publisher = "Elsevier BV",
number = "3",
}