Abstract
Proteins of the serum amyloid A (SAA) family have been remarkably conserved in evolution. Their biologic function(s) are not fully defined but they are likely to be a part of primordial host defense. We have detected a ∼ 12-kDa protein reacting with antibodies against serum amyloid A (SAA) in human colostrum by western blotting. Mass spectrometry identified the reactive species as SAA1, previously identified as a prominent member of the acute-phase response in serum. Our finding SAA1 in human colostrum contrasts with bovine, caprine and ovine colostrum where a species corresponding to putative SAA3 is uniformly present. SAA1 protein in human colostrum presumably contributes to neonatal protection.
Original language | English (US) |
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Pages (from-to) | 435-441 |
Number of pages | 7 |
Journal | FEBS Open Bio |
Volume | 8 |
Issue number | 3 |
DOIs | |
State | Published - Mar 2018 |
Keywords
- acute-phase
- amyloid
- colostrum
- serum amyloid A
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)