Abstract
Proteins of the serum amyloid A (SAA) family have been remarkably conserved in evolution. Their biologic function(s) are not fully defined but they are likely to be a part of primordial host defense. We have detected a ∼ 12-kDa protein reacting with antibodies against serum amyloid A (SAA) in human colostrum by western blotting. Mass spectrometry identified the reactive species as SAA1, previously identified as a prominent member of the acute-phase response in serum. Our finding SAA1 in human colostrum contrasts with bovine, caprine and ovine colostrum where a species corresponding to putative SAA3 is uniformly present. SAA1 protein in human colostrum presumably contributes to neonatal protection.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 435-441 |
| Number of pages | 7 |
| Journal | FEBS Open Bio |
| Volume | 8 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 2018 |
Keywords
- acute-phase
- amyloid
- colostrum
- serum amyloid A
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
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Cite this
Sack, G. H., Zachara, N., Rosenblum, N., Talbot, C. C., Kreimer, S., Cole, R., & McDonald, T. L. (2018). Serum amyloid A1 (SAA1) protein in human colostrum. FEBS Open Bio, 8(3), 435-441. https://doi.org/10.1002/2211-5463.12383