Serum concentrations of prostacyclin and thromboxane in children before, during, and after cardiopulmonary bypass

W. H. Fleming, L. B. Sarafian, M. P. Leuschen, M. C. Newland, E. M. Kennedy, J. D. Kugler, J. W. Chapin, B. J. Hurlbert, D. L. Bolam, R. M. Nelson

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Twenty-six consecutive pediatric patients undergoing reparative procedures necessitating cardiopulmonary bypass were prospectively studied to determine changes in serum levels of 6-keto-prostaglandin F(1α) and thomboxane B2. Cardiac lesions included acyanotic lesions (five patients), obstructive lesions (10 patients), and right-to-left shunts (11 patients). There was a significant (p < 0.05) increase in 6-keto-prostaglandin F(1α) from preoperative levels to levels measured at the time of arterial and venous cannula insertion. This concentration was maintained throughout cardiopulmonary bypass and remained significantly elevated (p < 0.001) in the recovery room, but returned to preoperative levels by the morning after the operation. Preoperative levels of thromboxane B2 varied widely and were not significantly different from intraoperative levels. The postoperative levels of thromboxane B2, however, were significantly different (p < 0.05) from the intraoperative levels. In the pediatric age group undergoing cardiopulmonary bypass, 6-keto-prostaglandin F(1α) and thromboxane B2 change during bypass but do not significantly differ when preoperative levels are compared to postoperative values.

Original languageEnglish (US)
Pages (from-to)73-78
Number of pages6
JournalJournal of Thoracic and Cardiovascular Surgery
Volume92
Issue number1
StatePublished - Sep 4 1986

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

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    Fleming, W. H., Sarafian, L. B., Leuschen, M. P., Newland, M. C., Kennedy, E. M., Kugler, J. D., Chapin, J. W., Hurlbert, B. J., Bolam, D. L., & Nelson, R. M. (1986). Serum concentrations of prostacyclin and thromboxane in children before, during, and after cardiopulmonary bypass. Journal of Thoracic and Cardiovascular Surgery, 92(1), 73-78.