SERUM LEVELS OF GAMMA-AMINOBUTYRIC-ACID-LIKE ACTIVITY IN ACUTE AND CHRONIC HEPATOCELLULAR DISEASE

P. Ferenci; G. Kleinberger; D. F. Schafer; J. H. Hoofnagle; E. A. Jones

doi:10.1016/S0140-6736(83)90735-3

SERUM LEVELS OF GAMMA-AMINOBUTYRIC-ACID-LIKE ACTIVITY IN ACUTE AND CHRONIC HEPATOCELLULAR DISEASE

P. Ferenci, G. Kleinberger, D. F. Schafer, J. H. Hoofnagle, E. A. Jones

Research output: Contribution to journal › Article › peer-review

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Abstract

Serum levels of GABA (gamma-aminobutyric acid)-like activity were measured by a radioreceptor assay in 22 healthy subjects and 170 patients with liver diseases. Levels were within normal limits (mean±SEM in healthy controls 0 ·52±0·04 μmol/l; range 0·2-0·8 μmol/l GABA equivalents) in most patients with uncomplicated acute viral hepatitis, compensated chronic hepatitis, and primary biliary cirrhosis (PBC). In 96% of patients with compensated (non-PBC) cirrhosis levels were slightly high (1·5+0·06 μmol/l). In 4 patients with.

Original language	English (US)
Pages (from-to)	811-814
Number of pages	4
Journal	The Lancet
Volume	322
Issue number	8354
DOIs	https://doi.org/10.1016/S0140-6736(83)90735-3
State	Published - Oct 8 1983
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

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title = "SERUM LEVELS OF GAMMA-AMINOBUTYRIC-ACID-LIKE ACTIVITY IN ACUTE AND CHRONIC HEPATOCELLULAR DISEASE",

abstract = "Serum levels of GABA (gamma-aminobutyric acid)-like activity were measured by a radioreceptor assay in 22 healthy subjects and 170 patients with liver diseases. Levels were within normal limits (mean±SEM in healthy controls 0 ·52±0·04 μmol/l; range 0·2-0·8 μmol/l GABA equivalents) in most patients with uncomplicated acute viral hepatitis, compensated chronic hepatitis, and primary biliary cirrhosis (PBC). In 96% of patients with compensated (non-PBC) cirrhosis levels were slightly high (1·5+0·06 μmol/l). In 4 patients with.",

author = "P. Ferenci and G. Kleinberger and Schafer, {D. F.} and Hoofnagle, {J. H.} and Jones, {E. A.}",

note = "Funding Information: P. F. was supported by the Max Kade Foundation.",

year = "1983",

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doi = "10.1016/S0140-6736(83)90735-3",

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T1 - SERUM LEVELS OF GAMMA-AMINOBUTYRIC-ACID-LIKE ACTIVITY IN ACUTE AND CHRONIC HEPATOCELLULAR DISEASE

AU - Ferenci, P.

AU - Kleinberger, G.

AU - Schafer, D. F.

AU - Hoofnagle, J. H.

AU - Jones, E. A.

N1 - Funding Information: P. F. was supported by the Max Kade Foundation.

PY - 1983/10/8

Y1 - 1983/10/8

N2 - Serum levels of GABA (gamma-aminobutyric acid)-like activity were measured by a radioreceptor assay in 22 healthy subjects and 170 patients with liver diseases. Levels were within normal limits (mean±SEM in healthy controls 0 ·52±0·04 μmol/l; range 0·2-0·8 μmol/l GABA equivalents) in most patients with uncomplicated acute viral hepatitis, compensated chronic hepatitis, and primary biliary cirrhosis (PBC). In 96% of patients with compensated (non-PBC) cirrhosis levels were slightly high (1·5+0·06 μmol/l). In 4 patients with.

AB - Serum levels of GABA (gamma-aminobutyric acid)-like activity were measured by a radioreceptor assay in 22 healthy subjects and 170 patients with liver diseases. Levels were within normal limits (mean±SEM in healthy controls 0 ·52±0·04 μmol/l; range 0·2-0·8 μmol/l GABA equivalents) in most patients with uncomplicated acute viral hepatitis, compensated chronic hepatitis, and primary biliary cirrhosis (PBC). In 96% of patients with compensated (non-PBC) cirrhosis levels were slightly high (1·5+0·06 μmol/l). In 4 patients with.

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SERUM LEVELS OF GAMMA-AMINOBUTYRIC-ACID-LIKE ACTIVITY IN ACUTE AND CHRONIC HEPATOCELLULAR DISEASE

Abstract

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