TY - JOUR
T1 - SET-domain proteins of the Su(var)3-9, E(z) and Trithorax families
AU - Alvarez-Venegas, Raul
AU - Avramova, Zoya
PY - 2002/2/20
Y1 - 2002/2/20
N2 - SET-domain (SET: Su(var)3-9, E(z) and Trithorax)-containing proteins were collected through sequence searches of the available databases. After removing redundancies, the proteins belonging to three families, SU(VAR)3-9, E(Z) and TRITHORAX, were selected. Analysis of the relationship between the different members is based on pairwise alignment, compilation, and comparison of their SET-domains. The level of homology of the SET-domains defined the distribution of the proteins into families and into clades within the families. The architecture of the entire protein supported the distribution pattern built upon SET-domain similarity. Parallel cladistic and protein-architecture analyses outlined two plausible criteria for predicting function.
AB - SET-domain (SET: Su(var)3-9, E(z) and Trithorax)-containing proteins were collected through sequence searches of the available databases. After removing redundancies, the proteins belonging to three families, SU(VAR)3-9, E(Z) and TRITHORAX, were selected. Analysis of the relationship between the different members is based on pairwise alignment, compilation, and comparison of their SET-domains. The level of homology of the SET-domains defined the distribution of the proteins into families and into clades within the families. The architecture of the entire protein supported the distribution pattern built upon SET-domain similarity. Parallel cladistic and protein-architecture analyses outlined two plausible criteria for predicting function.
KW - Chromatin modifier
KW - Database analysis
KW - Evolution and homology of SET-domain genes
UR - http://www.scopus.com/inward/record.url?scp=0037138359&partnerID=8YFLogxK
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U2 - 10.1016/S0378-1119(02)00401-8
DO - 10.1016/S0378-1119(02)00401-8
M3 - Review article
C2 - 12039029
AN - SCOPUS:0037138359
SN - 0378-1119
VL - 285
SP - 25
EP - 37
JO - Gene
JF - Gene
IS - 1-2
ER -