SET-domain proteins of the Su(var)3-9, E(z) and Trithorax families

Raul Alvarez-Venegas, Zoya Avramova

Research output: Contribution to journalReview articlepeer-review

73 Scopus citations


SET-domain (SET: Su(var)3-9, E(z) and Trithorax)-containing proteins were collected through sequence searches of the available databases. After removing redundancies, the proteins belonging to three families, SU(VAR)3-9, E(Z) and TRITHORAX, were selected. Analysis of the relationship between the different members is based on pairwise alignment, compilation, and comparison of their SET-domains. The level of homology of the SET-domains defined the distribution of the proteins into families and into clades within the families. The architecture of the entire protein supported the distribution pattern built upon SET-domain similarity. Parallel cladistic and protein-architecture analyses outlined two plausible criteria for predicting function.

Original languageEnglish (US)
Pages (from-to)25-37
Number of pages13
Issue number1-2
StatePublished - Feb 20 2002


  • Chromatin modifier
  • Database analysis
  • Evolution and homology of SET-domain genes

ASJC Scopus subject areas

  • Genetics


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