Severe chronic active epstein-barr virus infection syndrome and adenovirus type-2 infection

Motohiko Okano, Geoffrey M. Thiele, David T. Purtilo

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12 Scopus citations


Four patients from 4 to 24 years of age (3 males, 1 female) with generalized lymphadenopathy, hepatosplenomegaly, and intermittent fever associated with chronic active Epstein-Barr virus (EBV) infection were investigated. Laboratory data showed polyclonal gammopathy and a tendency for bone marrow suppression. Noteworthy were the extremely elevated immunoglobulin G (IgG) antibody titers to Epstein-Barr viral capsid antigen (VCA) (range, 10, 240-81, 920) and early antigen (EA) (range, 1, 280- 40, 960). All patients had IgA antibodies to VCA and EA. Subtle, heterogeneous immune functional defects were observed in all four patients. Another unusual feature was our inability to establish spontaneous or B95-8 EBV- immortalized lymphoblastiod cell lines (LCLs) due to a marked cytopathic effect (CPE). Thus, we investigated for other viruses. Both IgG and IgM antibodies to adenovirus type-2 (Ad-2) were positive by enzyme-linked immunosorbent assay (ELISA) and immunofluorescence (IF) test, suggesting recent or activated Ad-2 infection had occurred. Dual active EBV and Ad-2 infections were likely etiologic in this severe chronic active EBV infection syndrome.

Original languageEnglish (US)
Pages (from-to)168-173
Number of pages6
JournalAmerican Journal of Pediatric Hematology/Oncology
Issue number2
StatePublished - 1990


  • Adenovirus
  • Barr virus (EBV) infection
  • Chronic active epstein
  • Immunodeficiency

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology


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