Abstract
Oxaliplatin-based combination chemotherapy is an option for first-line therapy of metastatic colorectal cancer. It is associated with acute hyperexcitability of motor and sensory nerves, and a cumulative sensory axonal neuropathy. We describe a 56-year-old male with metastatic colorectal cancer treated with oxaliplatin and capecitabine who developed a rapidly ascending motor and sensory neuropathy, which rendered him wheelchair-bound. Heightened clinical suspicion for possible oxaliplatin-induced motor neuropathies may be warranted.
Original language | English (US) |
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Pages (from-to) | 733-735 |
Number of pages | 3 |
Journal | Anti-Cancer Drugs |
Volume | 15 |
Issue number | 7 |
DOIs | |
State | Published - Aug 2004 |
Externally published | Yes |
Keywords
- Oxaliplatin-based chemotherapy
- Sensory-motor polyneuropathy
ASJC Scopus subject areas
- Oncology
- Pharmacology
- Pharmacology (medical)
- Cancer Research