Severe disabling sensory-motor polyneuropathy during oxaliplatin-based chemotherapy

Gregory D. Leonard, Michael R. Wagner, Mary G. Quinn, Jean L. Grem

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Oxaliplatin-based combination chemotherapy is an option for first-line therapy of metastatic colorectal cancer. It is associated with acute hyperexcitability of motor and sensory nerves, and a cumulative sensory axonal neuropathy. We describe a 56-year-old male with metastatic colorectal cancer treated with oxaliplatin and capecitabine who developed a rapidly ascending motor and sensory neuropathy, which rendered him wheelchair-bound. Heightened clinical suspicion for possible oxaliplatin-induced motor neuropathies may be warranted.

Original languageEnglish (US)
Pages (from-to)733-735
Number of pages3
JournalAnti-Cancer Drugs
Issue number7
StatePublished - Aug 2004
Externally publishedYes


  • Oxaliplatin-based chemotherapy
  • Sensory-motor polyneuropathy

ASJC Scopus subject areas

  • Oncology
  • Pharmacology
  • Pharmacology (medical)
  • Cancer Research


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