Severe left ventricular systolic dysfunction may reverse with renal transplantation: Uremic cardiomyopathy and cardiorenal syndrome

R. Zolty, P. J. Hynes, T. J. Vittorio

Research output: Contribution to journalShort surveypeer-review

45 Scopus citations

Abstract

Chronic heart failure (CHF) and chronic kidney disease (CKD) are serious medical conditions with significant morbidity and mortality. Emerging evidence indicates that the function of these two organ systems are affected by each other in a complex interplay. Most patients with CKD suffer frequently from cardiac abnormalities including left ventricular hypertrophy (LVH), left ventricular dilatation (LVD), left ventricular (LV) diastolic and/or systolic dysfunction. Although previously thought that LV systolic dysfunction was an absolute contraindication to renal transplantation, several observational studies have shown this not to be true and that transplantation can lead to significant improvement in LV systolic function. Furthermore, correction of the uremic state by renal transplantation leads to improvement of LVD and possibly regression of LVH. In fact, the reduction of LVH postkidney transplantation was shown to be dependent on adequate renal function and hypertension control. Diabetes mellitus does not seem to be a confounding factor in the improvement of uremic cardiomyopathy with renal transplantation.

Original languageEnglish (US)
Pages (from-to)2219-2224
Number of pages6
JournalAmerican Journal of Transplantation
Volume8
Issue number11
DOIs
StatePublished - Nov 2008
Externally publishedYes

Keywords

  • Chronic kidney disease (CKD)
  • Congestive heart failure
  • Posttransplantation
  • Pretransplantation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

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