Severe sepsis and septic shock: Clinical overview and update on management

Kelly A. Cawcutt, Steve G. Peters

Research output: Contribution to journalReview articlepeer-review

70 Scopus citations


Sepsis is among the oldest themes in medicine; however, despite modern advances, it remains a leading cause of death in the United States. Every clinician should be able to recognize the signs and symptoms of sepsis, along with early management strategies, to expeditiously provide appropriate care and decrease resultant morbidity and mortality. This review addresses the definitions, pathogenesis, clinical manifestations, management, and outcomes of patients with sepsis, severe sepsis, and septic shock.

Original languageEnglish (US)
Pages (from-to)1572-1578
Number of pages7
JournalMayo Clinic Proceedings
Issue number11
StatePublished - Nov 1 2014
Externally publishedYes


  • Abbreviations and Acronyms CVP central venous pressure EGDT early-goal-directed therapy ICU intensive care unit IVC inferior vena cava MAP mean arterial pressure SvO mixed venous oxygen saturation

ASJC Scopus subject areas

  • General Medicine


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