Severer nodular lesion in white matter than in gray matter in simian immunodeficiency virus-infected monkey, but not closely correlated with viral infection

Jingdong Zhang, Howard Fox, Huangui Xiong

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Immune cell accumulation and white matter anomaly are common features of HIV (human immunodeficiency virus) -infected patients in combination antiretroviral therapy (cART) era. Neuroimaging tests on cART treated patients displayed prominent diffuse white matter lesions. Notably, immune cell nodular lesion (NL) was a conspicuous type of pathological change in HIV/SIV (simian immunodeficiency virus) infected brain before cART. Therefore, we used SIV infected brain to investigate the distribution of those NLs in gray and white matters. We found a significant higher number of NLs in white matter than that in gray matter. However, virus infection correlated with macrophage NLs but not with microglia NLs, especially in white matter. In addition, NLs interrupted white matter integrity more severely, since even tiny nodules could disconnect nerve fibers in white matter tracts. In the gray matter with dense myelinated axons, NLs obviously encroached those fibers; in the area of few myelinated axons, small nodules well co-localized with extracellular matrix between neurons.

Original languageEnglish (US)
Pages (from-to)292-300
Number of pages9
JournalJournal of Biomedical Research
Volume34
Issue number4
DOIs
StatePublished - 2020

Keywords

  • microglia nodules
  • nerve fiber disconnection
  • nodular lesions
  • perivascular cuffing
  • simian immunodeficiency virus-infected monkey
  • white matter tract

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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