TY - JOUR
T1 - Sex-dependent gene expression and evolution of the Drosophila transcriptome
AU - Ranz, José M.
AU - Castillo-Davis, Cristian I.
AU - Meiklejohn, Colin D.
AU - Hartl, Daniel L.
PY - 2003/6/13
Y1 - 2003/6/13
N2 - Comparison of the gene-expression profiles between adults of Drosophila melanogaster and Drosophila simulans has uncovered the evolution of genes that exhibit sex-dependent regulation. Approximately half the genes showed differences in expression between the species, and among these, ∼83% involved a gain, loss, increase, decrease, or reversal of sex-biased expression. Most of the interspecific differences in messenger RNA abundance affect male-biased genes. Genes that differ in expression between the species showed functional clustering only if they were sex-biased. Our results suggest that sex-dependent selection may drive changes in expression of many of the most rapidly evolving genes in the Drosophila transcriptome.
AB - Comparison of the gene-expression profiles between adults of Drosophila melanogaster and Drosophila simulans has uncovered the evolution of genes that exhibit sex-dependent regulation. Approximately half the genes showed differences in expression between the species, and among these, ∼83% involved a gain, loss, increase, decrease, or reversal of sex-biased expression. Most of the interspecific differences in messenger RNA abundance affect male-biased genes. Genes that differ in expression between the species showed functional clustering only if they were sex-biased. Our results suggest that sex-dependent selection may drive changes in expression of many of the most rapidly evolving genes in the Drosophila transcriptome.
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U2 - 10.1126/science.1085881
DO - 10.1126/science.1085881
M3 - Article
C2 - 12805547
AN - SCOPUS:0037504137
VL - 300
SP - 1742
EP - 1745
JO - Science
JF - Science
SN - 0036-8075
IS - 5626
ER -