Short communication: In utero HIV infection is associated with an increased risk of nevirapine resistance in ugandan infants who were exposed to perinatal single dose nevirapine

Jessica D. Church, Anthony Mwatha, Danstan Bagenda, Saad B. Omer, Deborah Donnell, Philippa Musoke, Clemensia Nakabiito, Chineta Eure, Paul Bakaki, Flavia Matovu, Michael C. Thigpen, Laura A. Guay, Michelle McConnell, Mary Glenn Fowler, J. Brooks Jackson, Susan H. Eshleman

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Use of single dose nevirapine (sdNVP) to prevent HIV mother-to-child transmission is associated with the emergence of NVP resistance in many infants who are HIV infected despite prophylaxis. We combined results from four clinical trials to analyze predictors of NVP resistance in sdNVP-exposed Ugandan infants. Samples were tested with the ViroSeq HIV Genotyping System and a sensitive point mutation assay (LigAmp, for detection of K103N, Y181C, and G190A). NVP resistance was detected at 6-8 weeks in 36 (45.0%) of 80 infants using ViroSeq and 33 (45.8%) of 72 infants using LigAmp. NVP resistance was more frequent among infants who were infected in utero than among infants who were diagnosed with HIV infection after birth by 6-8 weeks of age. Detection of NVP resistance at 6-8 weeks was not associated with HIV subtype (A vs. D), pre-NVP maternal viral load or CD4 cell count, infant viral load at 6-8 weeks, or infant sex. NVP resistance was still detected in some infants 6-12 months after sdNVP exposure. In this study, in utero HIV infection was the only factor associated with detection of NVP resistance in infants 6-8 weeks after sdNVP exposure.

Original languageEnglish (US)
Pages (from-to)673-677
Number of pages5
JournalAIDS Research and Human Retroviruses
Volume25
Issue number7
DOIs
StatePublished - Jul 1 2009

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Short communication: In utero HIV infection is associated with an increased risk of nevirapine resistance in ugandan infants who were exposed to perinatal single dose nevirapine'. Together they form a unique fingerprint.

  • Cite this

    Church, J. D., Mwatha, A., Bagenda, D., Omer, S. B., Donnell, D., Musoke, P., Nakabiito, C., Eure, C., Bakaki, P., Matovu, F., Thigpen, M. C., Guay, L. A., McConnell, M., Fowler, M. G., Jackson, J. B., & Eshleman, S. H. (2009). Short communication: In utero HIV infection is associated with an increased risk of nevirapine resistance in ugandan infants who were exposed to perinatal single dose nevirapine. AIDS Research and Human Retroviruses, 25(7), 673-677. https://doi.org/10.1089/aid.2009.0003