TY - JOUR
T1 - Short latency vestibular responses to pulsed linear acceleration
AU - Jones, Timothy A.
AU - Pedersen, Todd L.
N1 - Funding Information:
Received September 1988 from the University of Nebraska Medical Center, College of Dentistry, Lincoln. Accepted for publication March 15, 1989. Supported by NASA NA2-430, State of Nebraska Department of Health LB 506-86-23; 87-26, and College of Dentistry Research Funds 86-13, 86-14, and 86-15. Presented in part at the annual meetings of the American Society for Gravitational and Space Biology, October X9-21, 1987 (Logan, UT) and October 20-23, 1988 [Washington, DC). Address correspondence and reprint requests t;Timothi A. Tones, PhD, Deaartment of Oral Biolow. Universitv of Nel&aska Medical Center, College of Dentistry, 4O<h & Holdrege St, Lincoln, NE 68583-0740. 0 1989 by W.B. Saunders Company. 0196-0709/89/1005-0008$5.00/O
PY - 1989
Y1 - 1989
N2 - Far-field vestibular responses to pulsed linear cranial acceleration have not been reported in detail for any species. In this study, precisely defined pulsed linear accelerations were used to elicit vestibular neural responses recorded from the surfaces of the skulls of 23 White Leghorn chicks. Traditional signal averaging techniques were used to resolve responses. At moderate intensities, responses consisted of a series of four to seven dominant peaks occurring within a period of 8 ms, having amplitudes between 0.3 and 20 μV peak-to-peak. The mean response threshold was 0.120 ± 0.045 g. Latencies and amplitudes varied systematically as a function of stimulus intensity. Hypothermia prolonged response latencies. Response peaks did not invert on stimulus inversion, were present in response to cranial but not trunk acceleration, were not attenuated by broad-band auditory masking or by ambient light conditions, and disappeared with complete bilateral destruction of the labyrinth. The results rule out major contributions from auditory, somatosensory, and visual modalities and support the hypothesis that the responses reflect bilateral neural activity in the vestibular system. The findings suggest that direct noninvasive assessment of peripheral vestibular function can be achieved using pulsed linear acceleration stimuli.
AB - Far-field vestibular responses to pulsed linear cranial acceleration have not been reported in detail for any species. In this study, precisely defined pulsed linear accelerations were used to elicit vestibular neural responses recorded from the surfaces of the skulls of 23 White Leghorn chicks. Traditional signal averaging techniques were used to resolve responses. At moderate intensities, responses consisted of a series of four to seven dominant peaks occurring within a period of 8 ms, having amplitudes between 0.3 and 20 μV peak-to-peak. The mean response threshold was 0.120 ± 0.045 g. Latencies and amplitudes varied systematically as a function of stimulus intensity. Hypothermia prolonged response latencies. Response peaks did not invert on stimulus inversion, were present in response to cranial but not trunk acceleration, were not attenuated by broad-band auditory masking or by ambient light conditions, and disappeared with complete bilateral destruction of the labyrinth. The results rule out major contributions from auditory, somatosensory, and visual modalities and support the hypothesis that the responses reflect bilateral neural activity in the vestibular system. The findings suggest that direct noninvasive assessment of peripheral vestibular function can be achieved using pulsed linear acceleration stimuli.
KW - gravity receptors
KW - vestibular evoked potentials
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U2 - 10.1016/0196-0709(89)90108-7
DO - 10.1016/0196-0709(89)90108-7
M3 - Article
C2 - 2817248
AN - SCOPUS:0024422019
VL - 10
SP - 327
EP - 335
JO - American Journal of Otolaryngology - Head and Neck Medicine and Surgery
JF - American Journal of Otolaryngology - Head and Neck Medicine and Surgery
SN - 0196-0709
IS - 5
ER -