Short-Term Outcomes of Neonates with Hypoxic-Ischemic Encephalopathy Receiving Active Versus Passive Cooling During Transport

Ricky Rana, Ashleigh Manktelow, Elizabeth Lyden, Eric S. Peeples

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Therapeutic hypothermia (TH) is the only currently approved treatment for neonatal hypoxic-ischemic encephalopathy (HIE) and must be started within 6 hours to optimize effectiveness. This narrow therapeutic window often requires initiation of TH before or during transport. The goal of this study was to assess the effects of servo-controlled TH versus passive hypothermia during transport on short-term outcomes in newborns with HIE. This was a single-center retrospective case-control study of neonates with HIE treated with active or passive TH during transport. Primary outcomes included brain injury on magnetic resonance imaging (MRI) and presence of seizures. Seventy-six neonates were included - 13 active and 63 passive. The active TH group was more likely to arrive within goal temperature. No difference was noted between groups in seizures or TH complications. Active TH was associated with increased injury on MRI. Active TH resulted in tighter temperature control, but no improvement in short-term outcomes in our cohort. The MRI findings may be due to differences in overall disease severity, which could not be adjusted for, given the modest sample size.

Original languageEnglish (US)
Pages (from-to)205-210
Number of pages6
JournalTherapeutic hypothermia and temperature management
Volume14
Issue number3
DOIs
StatePublished - Sep 1 2024

Keywords

  • asphyxia
  • brain injury
  • seizures
  • servo controlled
  • therapeutic hypothermia

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Anesthesiology and Pain Medicine

Fingerprint

Dive into the research topics of 'Short-Term Outcomes of Neonates with Hypoxic-Ischemic Encephalopathy Receiving Active Versus Passive Cooling During Transport'. Together they form a unique fingerprint.

Cite this