@article{d2d263c32c0f4f8d944f330e3918eff8,
title = "Should IACUCs review scientific merit of animal research projects?",
abstract = "Whether IACUCs should review animal research protocols for scientific merit is not addressed in the federal regulations, resulting in ongoing confusion on the subject. The authors examine this issue, discuss the pros and cons, suggest how IACUCs can go about reviewing protocols for scientific merit, and question what effect recent changes in regulations will have on this issue.",
author = "Mann, {Michael D.} and Prentice, {Ernest D.}",
note = "Funding Information: required changes will have on the proposal{\textquoteright}s approval. Will the NIH reconsider such proposals when the modifications are substantive, or will the changes simply be entered into the file of the grant? What about the IACUC review that results in a refinement to the protocol, which, in turn, will reduce animal pain and distress but also requires an alteration in the experimental design—for example, the experiment is not as “tightly controlled?” How will the NIH respond to an IACUC-mandated redesign of an experiment? To pursue this issue further, how will the NIH respond to an IACUC review that mandates an expensive live animal replacement, which cannot be accommodated by the budget in the grant proposal? Will the NIH reconsider the funding level? Finally, what about the reaction of an investigator who receives notification of funding from the NIH but finds that the IACUC either does not approve the research or mandates changes that either delay the award or kill it? This potential conflict is not unique to the IACUC. The institution or state legislature can restrict the kinds of research conducted by the institution regardless of the source of funding, merit review outcome, or IACUC approval. These are just a few of the thorny questions that could arise when the IACUC does not cede its authority and responsibility for review to the NIH.",
year = "2004",
month = jan,
doi = "10.1038/laban0104-26",
language = "English (US)",
volume = "33",
pages = "26--31",
journal = "Lab Animal",
issn = "0093-7355",
publisher = "Nature Publishing Group",
number = "1",
}