Shuttling components of nuclear import machinery involved in nuclear translocation of steroid receptors exit nucleus via exportin-1/CRM-1* independent pathway

Sanjay Kumar, Nagendra K. Chaturvedi, Mayumi Nishi, Mitsuhiro Kawata, Rakesh K. Tyagi

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

The nucleocytoplasmic transport processes are mediated by soluble transport factors constantly navigating between nuclear and cytoplasmic compartments. Our understanding about nuclear export of general 'nuclear import factors' that deliver the cargo to the nucleus is still fragmentary. Utilizing green fluorescent protein tagged glucocorticoid receptor (GR) and relA as our working model and with judicious use of LMB, we show in living cells that all the soluble components of the nuclear import machinery exit nucleus via exportin1/CRM1 independent pathway(s).

Original languageEnglish (US)
Pages (from-to)73-77
Number of pages5
JournalBiochimica et Biophysica Acta - Molecular Cell Research
Volume1691
Issue number2-3
DOIs
StatePublished - May 3 2004

Keywords

  • Leptomycin
  • Nuclear export
  • Nuclear import
  • Steroid receptor

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Shuttling components of nuclear import machinery involved in nuclear translocation of steroid receptors exit nucleus via exportin-1/CRM-1* independent pathway'. Together they form a unique fingerprint.

Cite this