Sickle cell disease and malaria morbidity: A tale with two tails

Thomas N. Williams; Stephen K. Obaro

doi:10.1016/j.pt.2011.02.004

Sickle cell disease and malaria morbidity: A tale with two tails

Thomas N. Williams, Stephen K. Obaro

Research output: Contribution to journal › Review article › peer-review

49 Scopus citations

Abstract

More than 230 000 children are born in Africa with sickle cell disease (SCD) each year: approximately 85% of all affected births worldwide. Although malaria is commonly viewed as a major problem for African patients with this condition, questions still remain about its relative importance as a cause of ill heath and death. In the absence of definitive studies investigating the contribution of malaria to morbidity and mortality in African children with SCD, policy makers will continue to lack the evidence on which to base appropriate management guidelines.

Original language	English (US)
Pages (from-to)	315-320
Number of pages	6
Journal	Trends in Parasitology
Volume	27
Issue number	7
DOIs	https://doi.org/10.1016/j.pt.2011.02.004
State	Published - Jul 2011
Externally published	Yes

ASJC Scopus subject areas

Parasitology
Infectious Diseases

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10.1016/j.pt.2011.02.004

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title = "Sickle cell disease and malaria morbidity: A tale with two tails",

abstract = "More than 230 000 children are born in Africa with sickle cell disease (SCD) each year: approximately 85% of all affected births worldwide. Although malaria is commonly viewed as a major problem for African patients with this condition, questions still remain about its relative importance as a cause of ill heath and death. In the absence of definitive studies investigating the contribution of malaria to morbidity and mortality in African children with SCD, policy makers will continue to lack the evidence on which to base appropriate management guidelines.",

author = "Williams, {Thomas N.} and Obaro, {Stephen K.}",

note = "Funding Information: TNW and SO conceived the paper. TNW wrote the first draft and both authors contributed to subsequent revisions. We thank our colleagues at both the Wellcome Trust Programme, Kenya and at the Michigan State University, USA, for helpful comments. TNW is funded by the Wellcome Trust (Grant #076934) and by the European Union Network 7 EVIMalR Consortium. SO is funded by a Faculty grant from Michigan State University, the United Nations Development Program and the Centre for Disease Control and Prevention, Atlanta, USA.",

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AB - More than 230 000 children are born in Africa with sickle cell disease (SCD) each year: approximately 85% of all affected births worldwide. Although malaria is commonly viewed as a major problem for African patients with this condition, questions still remain about its relative importance as a cause of ill heath and death. In the absence of definitive studies investigating the contribution of malaria to morbidity and mortality in African children with SCD, policy makers will continue to lack the evidence on which to base appropriate management guidelines.

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Sickle cell disease and malaria morbidity: A tale with two tails

Abstract

ASJC Scopus subject areas

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