Significance of both numerical and structural chromosomal abnormalities in clear cell sarcoma

Joni A. Travis, Julia A. Bridge

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

We analyzed cytogenetically two cases of clear cell sarcoma. The t(12;22)(q13;q13) hypothesized to be characteristic of clear cell sarcoma was detected in one of the two cases. Although this translocation was not observed in the other case; trisomy of chromosome 22 was, as were other numerical abnormalities. This latter observation has also been described in other reported studies of clear cell sarcoma. These findings confirm the nonrandomness of t(12;22)(q13;q13) in clear cell sarcoma, but also suggest that in its absence other abnormalities of chromosome 22 are significant. Trisomy 8, noted in both cases we report, as well as in previous studies, also appears to play an important role in clear cell sarcoma.

Original languageEnglish (US)
Pages (from-to)104-106
Number of pages3
JournalCancer genetics and cytogenetics
Volume64
Issue number2
DOIs
StatePublished - Dec 1992

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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