Significance of chromosomal abnormalities in a malignant giant cell tumor of bone

Julia A. Bridge, Barbara J. Mouron, James R. Neff, Paramjit S. Bhatia

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Cytogenetic analysis of a malignant giant cell tumor of the sacrum from a 62-year-old female revealed the following chromosomal complement: 47,XX,-1,-11,+22,del(2)(p22),t(7;7) (p22;q32),+der(1)t(1;11;21)(p32;q13;q22),+der(19)t(19;?)(q13.4;?),der(8)t(8;?)(p11;?),der(7)t(17;?)(p13;?). Metaphase cells with 92-127 chromosomes sharing identical structural abnormalities detected in the near-diploid cells were also observed. Several of these abnormalities have previously been described in the benign giant cell tumors supporting a direct relationship between these benign and malignant neoplastic counterparts.

Original languageEnglish (US)
Pages (from-to)87-92
Number of pages6
JournalCancer genetics and cytogenetics
Volume57
Issue number1
DOIs
StatePublished - Nov 1991

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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