TY - JOUR
T1 - Significance of chromosomal abnormalities in a malignant giant cell tumor of bone
AU - Bridge, Julia A.
AU - Mouron, Barbara J.
AU - Neff, James R.
AU - Bhatia, Paramjit S.
N1 - Funding Information:
The authors wish to thank Ms. Kathy Sarratt for her valuable secretarial assistance. This work was supported in part by a grant through the Orthopaedic Research Education Foundation (OREF).
PY - 1991/11
Y1 - 1991/11
N2 - Cytogenetic analysis of a malignant giant cell tumor of the sacrum from a 62-year-old female revealed the following chromosomal complement: 47,XX,-1,-11,+22,del(2)(p22),t(7;7) (p22;q32),+der(1)t(1;11;21)(p32;q13;q22),+der(19)t(19;?)(q13.4;?),der(8)t(8;?)(p11;?),der(7)t(17;?)(p13;?). Metaphase cells with 92-127 chromosomes sharing identical structural abnormalities detected in the near-diploid cells were also observed. Several of these abnormalities have previously been described in the benign giant cell tumors supporting a direct relationship between these benign and malignant neoplastic counterparts.
AB - Cytogenetic analysis of a malignant giant cell tumor of the sacrum from a 62-year-old female revealed the following chromosomal complement: 47,XX,-1,-11,+22,del(2)(p22),t(7;7) (p22;q32),+der(1)t(1;11;21)(p32;q13;q22),+der(19)t(19;?)(q13.4;?),der(8)t(8;?)(p11;?),der(7)t(17;?)(p13;?). Metaphase cells with 92-127 chromosomes sharing identical structural abnormalities detected in the near-diploid cells were also observed. Several of these abnormalities have previously been described in the benign giant cell tumors supporting a direct relationship between these benign and malignant neoplastic counterparts.
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U2 - 10.1016/0165-4608(91)90193-X
DO - 10.1016/0165-4608(91)90193-X
M3 - Article
C2 - 1756489
AN - SCOPUS:0026342933
SN - 0165-4608
VL - 57
SP - 87
EP - 92
JO - Cancer genetics and cytogenetics
JF - Cancer genetics and cytogenetics
IS - 1
ER -