Objective To study the expression of MUM-1/IRF4 and its significance in follicular lymphoma. Methods Ninety-eight cases of follicular lymphoma were enrolled into the study. They were graded according to the 2008 WHO criteria. The expression of MUM-1/IRF4 protein and other markers (CDlO, bcl-6, bcl-2 and Ki-67) was studied using tissue microarray and immunohistochemistry. Results Amongst the 98 cases studied, there were 24 grade 1 cases, 30 grade 2 cases, 26 grade 3A cases and 18 were grade 3B cases. The rates of expression of MUM-1/IRF4, CD10, bcl-6, bcl-2 and Ki-67 ( ≥25% ) were 39. 8% ( 39/98 ) , 62.2% ( 61/98 ) , 80.6% ( 79/98 ) , 87.8% ( 86/98 ) and 50.0% ( 49/98 ) , respectively. MUM-1/IRF4 predominantly expressed in high-grade follicular lymphoma and showed a significantly positive correlation with lymphoma grade ( r = 0.628 ,P=0.000) and Ki-67 index ( r = 0.473 , P = 0.000). MUM-1/IRF4 expression had a significantly negative correlation with CD10 expression (r = -0.597 ,P =0.000) , but no correlation with bcl-6 and bcl-2 expression. Conclusions MUM-1/IRF4 expression is significantly higher in high-grade follicular lymphoma, indicating that these cases have a high proliferative activity, more aggressive behavior and poorer prognosis. MUM-1/IRF4, when strongly expressed, is another helpful marker for the diagnosis of high-grade follicular lymphoma.
|Original language||English (US)|
|Number of pages||4|
|Journal||Chinese Journal of Pathology|
|State||Published - Aug 8 2011|
- Microarray analysis
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