Significance of MUM-1/IRF4 protein expression in follicular lymphoma

Ying Ying Huo, Yi Pan, Bing Xin Guan, Ai Ju Fang, Bao Cun Sun, Geng Yin Zhou, Kai Fu, Bin Meng

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Objective To study the expression of MUM-1/IRF4 and its significance in follicular lymphoma. Methods Ninety-eight cases of follicular lymphoma were enrolled into the study. They were graded according to the 2008 WHO criteria. The expression of MUM-1/IRF4 protein and other markers (CDlO, bcl-6, bcl-2 and Ki-67) was studied using tissue microarray and immunohistochemistry. Results Amongst the 98 cases studied, there were 24 grade 1 cases, 30 grade 2 cases, 26 grade 3A cases and 18 were grade 3B cases. The rates of expression of MUM-1/IRF4, CD10, bcl-6, bcl-2 and Ki-67 ( ≥25% ) were 39. 8% ( 39/98 ) , 62.2% ( 61/98 ) , 80.6% ( 79/98 ) , 87.8% ( 86/98 ) and 50.0% ( 49/98 ) , respectively. MUM-1/IRF4 predominantly expressed in high-grade follicular lymphoma and showed a significantly positive correlation with lymphoma grade ( r = 0.628 ,P=0.000) and Ki-67 index ( r = 0.473 , P = 0.000). MUM-1/IRF4 expression had a significantly negative correlation with CD10 expression (r = -0.597 ,P =0.000) , but no correlation with bcl-6 and bcl-2 expression. Conclusions MUM-1/IRF4 expression is significantly higher in high-grade follicular lymphoma, indicating that these cases have a high proliferative activity, more aggressive behavior and poorer prognosis. MUM-1/IRF4, when strongly expressed, is another helpful marker for the diagnosis of high-grade follicular lymphoma.

Original languageEnglish (US)
Pages (from-to)528-531
Number of pages4
JournalChinese Journal of Pathology
Issue number8
StatePublished - Aug 8 2011


  • Follicular
  • Immunohistochemistry
  • Lymphoma
  • Microarray analysis

ASJC Scopus subject areas

  • Medicine(all)

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    Huo, Y. Y., Pan, Y., Guan, B. X., Fang, A. J., Sun, B. C., Zhou, G. Y., Fu, K., & Meng, B. (2011). Significance of MUM-1/IRF4 protein expression in follicular lymphoma. Chinese Journal of Pathology, 40(8), 528-531.