Similar immunological profiles between African endemic and human immunodeficiency virus type 1-associated epidemic Kaposi Sarcoma (KS) patients reveal the primary role of KS-associated herpesvirus in KS pathogenesis

Salum J. Lidenge; For Yue Tso; Owen Ngalamika; John R. Ngowi; Yasaman Mortazavi; Eun Hee Kwon; Danielle M. Shea; Veenu Minhas; Julius Mwaiselage; Charles Wood; John T. West

doi:10.1093/infdis/jiy654

Similar immunological profiles between African endemic and human immunodeficiency virus type 1-associated epidemic Kaposi Sarcoma (KS) patients reveal the primary role of KS-associated herpesvirus in KS pathogenesis

Salum J. Lidenge, For Yue Tso, Owen Ngalamika, John R. Ngowi, Yasaman Mortazavi, Eun Hee Kwon, Danielle M. Shea, Veenu Minhas, Julius Mwaiselage, Charles Wood, John T. West

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Abstract

Background. Kaposi sarcoma (KS)-associated herpesvirus (KSHV) is etiologically linked to all KS forms, but mechanisms underlying KS development are unclear. Te incidence of KS in human immunodefciency virus type 1-infected (HIV-1+) individuals implicates immune dysregulation; however, the lack of characterization of KSHV immune responses in endemic KS makes the role of HIV-1 unclear. Te study objective was to investigate the HIV-1 and KSHV roles in viral nucleic acid detection, antibody responses, and cytokine responses in polymerase chain reaction-confrmed epidemic KS and endemic KS patients and non-cancer controls from sub-Saharan Africa. Methods. KSHV viral DNA (vDNA), total anti-KSHV antibody, KSHV neutralizing antibody (nAb), and cytokines were quantifed. Results. KSHV vDNA was detectable in tumors but variably in plasma and peripheral blood mononuclear cells. Consistent with elevated antibody-associated cytokines (interleukin [IL] 6, IL-5, and IL-10), nAb titers were higher in epidemic KS and endemic KS patients than in controls (P <.05). Despite HIV-1 coinfection in epidemic KS, nAb titers were similar between epidemic KS and endemic KS patients (P = 0.3). Conclusions. Similarities in antibody and cytokine responses between epidemic and endemic KS patients suggest that KSHV drives KS pathogenesis, whereas HIV-1 exacerbates it.

Original language	English (US)
Pages (from-to)	1318-1328
Number of pages	11
Journal	Journal of Infectious Diseases
Volume	219
Issue number	8
DOIs	https://doi.org/10.1093/infdis/jiy654
State	Published - Apr 8 2019

Keywords

Cytokines
KSHV
Kaposi sarcoma
Neutralizing antibody
Sub-Saharan Africa

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

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Lidenge, S. J., Tso, F. Y., Ngalamika, O., Ngowi, J. R., Mortazavi, Y., Kwon, E. H., Shea, D. M., Minhas, V., Mwaiselage, J., Wood, C., & West, J. T. (2019). Similar immunological profiles between African endemic and human immunodeficiency virus type 1-associated epidemic Kaposi Sarcoma (KS) patients reveal the primary role of KS-associated herpesvirus in KS pathogenesis. Journal of Infectious Diseases, 219(8), 1318-1328. https://doi.org/10.1093/infdis/jiy654

Similar immunological profiles between African endemic and human immunodeficiency virus type 1-associated epidemic Kaposi Sarcoma (KS) patients reveal the primary role of KS-associated herpesvirus in KS pathogenesis. / Lidenge, Salum J.; Tso, For Yue; Ngalamika, Owen et al.
In: Journal of Infectious Diseases, Vol. 219, No. 8, 08.04.2019, p. 1318-1328.

Research output: Contribution to journal › Article › peer-review

Lidenge, SJ, Tso, FY, Ngalamika, O, Ngowi, JR, Mortazavi, Y, Kwon, EH, Shea, DM, Minhas, V, Mwaiselage, J, Wood, C & West, JT 2019, 'Similar immunological profiles between African endemic and human immunodeficiency virus type 1-associated epidemic Kaposi Sarcoma (KS) patients reveal the primary role of KS-associated herpesvirus in KS pathogenesis', Journal of Infectious Diseases, vol. 219, no. 8, pp. 1318-1328. https://doi.org/10.1093/infdis/jiy654

Lidenge SJ, Tso FY, Ngalamika O, Ngowi JR, Mortazavi Y, Kwon EH et al. Similar immunological profiles between African endemic and human immunodeficiency virus type 1-associated epidemic Kaposi Sarcoma (KS) patients reveal the primary role of KS-associated herpesvirus in KS pathogenesis. Journal of Infectious Diseases. 2019 Apr 8;219(8):1318-1328. doi: 10.1093/infdis/jiy654

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title = "Similar immunological profiles between African endemic and human immunodeficiency virus type 1-associated epidemic Kaposi Sarcoma (KS) patients reveal the primary role of KS-associated herpesvirus in KS pathogenesis",

abstract = "Background. Kaposi sarcoma (KS)-associated herpesvirus (KSHV) is etiologically linked to all KS forms, but mechanisms underlying KS development are unclear. Te incidence of KS in human immunodefciency virus type 1-infected (HIV-1+) individuals implicates immune dysregulation; however, the lack of characterization of KSHV immune responses in endemic KS makes the role of HIV-1 unclear. Te study objective was to investigate the HIV-1 and KSHV roles in viral nucleic acid detection, antibody responses, and cytokine responses in polymerase chain reaction-confrmed epidemic KS and endemic KS patients and non-cancer controls from sub-Saharan Africa. Methods. KSHV viral DNA (vDNA), total anti-KSHV antibody, KSHV neutralizing antibody (nAb), and cytokines were quantifed. Results. KSHV vDNA was detectable in tumors but variably in plasma and peripheral blood mononuclear cells. Consistent with elevated antibody-associated cytokines (interleukin [IL] 6, IL-5, and IL-10), nAb titers were higher in epidemic KS and endemic KS patients than in controls (P <.05). Despite HIV-1 coinfection in epidemic KS, nAb titers were similar between epidemic KS and endemic KS patients (P = 0.3). Conclusions. Similarities in antibody and cytokine responses between epidemic and endemic KS patients suggest that KSHV drives KS pathogenesis, whereas HIV-1 exacerbates it.",

keywords = "Cytokines, KSHV, Kaposi sarcoma, Neutralizing antibody, Sub-Saharan Africa",

author = "Lidenge, {Salum J.} and Tso, {For Yue} and Owen Ngalamika and Ngowi, {John R.} and Yasaman Mortazavi and Kwon, {Eun Hee} and Shea, {Danielle M.} and Veenu Minhas and Julius Mwaiselage and Charles Wood and West, {John T.}",

note = "Funding Information: Financial support. This work was supported by the National Cancer Institute, US National Institutes of Health (grant numbers RO1 CA75903, U54 CA190155, and U54 CA221204); the Fogarty International Center (grant number D43 TW010354); and the National Institute of General Medical Sciences (grant number P30 GM103509 to C. W.). O. N. is a Fogarty fellow. Publisher Copyright: {\textcopyright} 2018 The Author(s).",

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doi = "10.1093/infdis/jiy654",

language = "English (US)",

volume = "219",

pages = "1318--1328",

journal = "Journal of Infectious Diseases",

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TY - JOUR

T1 - Similar immunological profiles between African endemic and human immunodeficiency virus type 1-associated epidemic Kaposi Sarcoma (KS) patients reveal the primary role of KS-associated herpesvirus in KS pathogenesis

AU - Lidenge, Salum J.

AU - Tso, For Yue

AU - Ngalamika, Owen

AU - Ngowi, John R.

AU - Mortazavi, Yasaman

AU - Kwon, Eun Hee

AU - Shea, Danielle M.

AU - Minhas, Veenu

AU - Mwaiselage, Julius

AU - Wood, Charles

AU - West, John T.

N1 - Funding Information: Financial support. This work was supported by the National Cancer Institute, US National Institutes of Health (grant numbers RO1 CA75903, U54 CA190155, and U54 CA221204); the Fogarty International Center (grant number D43 TW010354); and the National Institute of General Medical Sciences (grant number P30 GM103509 to C. W.). O. N. is a Fogarty fellow. Publisher Copyright: © 2018 The Author(s).

PY - 2019/4/8

Y1 - 2019/4/8

N2 - Background. Kaposi sarcoma (KS)-associated herpesvirus (KSHV) is etiologically linked to all KS forms, but mechanisms underlying KS development are unclear. Te incidence of KS in human immunodefciency virus type 1-infected (HIV-1+) individuals implicates immune dysregulation; however, the lack of characterization of KSHV immune responses in endemic KS makes the role of HIV-1 unclear. Te study objective was to investigate the HIV-1 and KSHV roles in viral nucleic acid detection, antibody responses, and cytokine responses in polymerase chain reaction-confrmed epidemic KS and endemic KS patients and non-cancer controls from sub-Saharan Africa. Methods. KSHV viral DNA (vDNA), total anti-KSHV antibody, KSHV neutralizing antibody (nAb), and cytokines were quantifed. Results. KSHV vDNA was detectable in tumors but variably in plasma and peripheral blood mononuclear cells. Consistent with elevated antibody-associated cytokines (interleukin [IL] 6, IL-5, and IL-10), nAb titers were higher in epidemic KS and endemic KS patients than in controls (P <.05). Despite HIV-1 coinfection in epidemic KS, nAb titers were similar between epidemic KS and endemic KS patients (P = 0.3). Conclusions. Similarities in antibody and cytokine responses between epidemic and endemic KS patients suggest that KSHV drives KS pathogenesis, whereas HIV-1 exacerbates it.

AB - Background. Kaposi sarcoma (KS)-associated herpesvirus (KSHV) is etiologically linked to all KS forms, but mechanisms underlying KS development are unclear. Te incidence of KS in human immunodefciency virus type 1-infected (HIV-1+) individuals implicates immune dysregulation; however, the lack of characterization of KSHV immune responses in endemic KS makes the role of HIV-1 unclear. Te study objective was to investigate the HIV-1 and KSHV roles in viral nucleic acid detection, antibody responses, and cytokine responses in polymerase chain reaction-confrmed epidemic KS and endemic KS patients and non-cancer controls from sub-Saharan Africa. Methods. KSHV viral DNA (vDNA), total anti-KSHV antibody, KSHV neutralizing antibody (nAb), and cytokines were quantifed. Results. KSHV vDNA was detectable in tumors but variably in plasma and peripheral blood mononuclear cells. Consistent with elevated antibody-associated cytokines (interleukin [IL] 6, IL-5, and IL-10), nAb titers were higher in epidemic KS and endemic KS patients than in controls (P <.05). Despite HIV-1 coinfection in epidemic KS, nAb titers were similar between epidemic KS and endemic KS patients (P = 0.3). Conclusions. Similarities in antibody and cytokine responses between epidemic and endemic KS patients suggest that KSHV drives KS pathogenesis, whereas HIV-1 exacerbates it.

KW - Cytokines

KW - KSHV

KW - Kaposi sarcoma

KW - Neutralizing antibody

KW - Sub-Saharan Africa

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AN - SCOPUS:85064528385

SN - 0022-1899

VL - 219

SP - 1318

EP - 1328

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 8

ER -

Similar immunological profiles between African endemic and human immunodeficiency virus type 1-associated epidemic Kaposi Sarcoma (KS) patients reveal the primary role of KS-associated herpesvirus in KS pathogenesis

Abstract

Keywords

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