@article{b2c88c22d1404dd8af9c9bbd87e99686,
title = "Simple synthesis of endophenazine G and other phenazines and their evaluation as anti-methicillin-resistant Staphylococcus aureus agents",
abstract = "Community-associated methicillin resistant Staphylococcus aureus (CA-MRSA) has become a severe health concern because of its treatment difficulties. Herein, we report the synthesis and biological evaluation of two phenazine natural products and a series of phenazines that show promising activities against MRSA with MIC values in the low micromolar range. Basic studies revealed that these compounds are bacteriostatic agents. The most active compound also displayed promising IC50 values against HaCat cells. Finally, a QSAR model was developed to understand the key structural features of the molecules.",
keywords = "Antibacterial Agents, Bacterial Infections, Drug-resistant Bacteria, MRSA, Methicillin-Resistant Staphylococcus Aureus, Natural Product Synthesis, Phenazines",
author = "Martin Conda-Sheridan and Venkatareddy Udumula and Endres, {Jennifer L.} and Harper, {Caleb N.} and Lee Jaramillo and Zhong, {Haizhen A.} and Bayles, {Kenneth W.}",
note = "Funding Information: This work was support by the University of Nebraska Medical Center (Start-up funds, MC-S) and by NIH grant number PO1-AI083211 (KB). We thank Dr. David Oupicky for providing resources and space to conduct the cell studies. We thank Janice A. Taylor and James R. Talaska of the Advanced Microscopy Core Facility at the University of Nebraska Medical Center for providing assistance with confocal microscopy. Data reported in this manuscript was supported by an Institutional Development Award (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health under grant number P30 GM106397 . The CARLZEISS LSM is supported by the National Institutes of Health Shared Instrument Grant program: NIH S10-RR-027301 . The NMR Research Facility at UNMC (part of the Fred & Pamela Buffett Cancer Center) is supported by NIH grant number P30-CA036727 . Publisher Copyright: {\textcopyright} 2016 Elsevier Masson SAS",
year = "2017",
doi = "10.1016/j.ejmech.2016.09.079",
language = "English (US)",
volume = "125",
pages = "710--721",
journal = "CHIM.THER.",
issn = "0223-5234",
publisher = "Elsevier Masson SAS",
}