TY - GEN
T1 - Simulation and phantom studies of Contrast-Enhanced Dual Energy Mammography (CEDEM)
AU - Huang, Shih Ying
AU - Boone, John M.
AU - Zheng, Dandan
AU - Yang, Kai
AU - Packard, Nathan J.
AU - Burkett, George
PY - 2008
Y1 - 2008
N2 - Contrast-enhanced dual energy mammography (CEDEM) has been shown effective in enhancing the visibility of breast cancer in diagnostic mammographic images. The simulation and phantom studies of CEDEM were implemented to enhance acquisition techniques of a dedicated cone-beam breast CT scanner fabricated in our laboratory. CEDEM images were computer-simulated numerically, and the results were compared and validated with physical experiments using a custom-made breast-equivalent phantom with pseudo anatomical structures. The technique factors to be optimized included low- and high-energy x-ray spectra (kVp), spectra filters and mAs (x-ray tube current × scan time in second). Signal-difference-to-noise ratio (SDNR) of the log-weighted subtracted image was computed to optimize subtraction parameters using several combinations of breast compositions and thicknesses. Both simulation and phantom studies suggest that 40 kVp (filtered with 1.5 mm Al) and 50 kVp (filtered with 1.5 mm Al and 0.3 mm Cu) were the optimal spectra with the highest SDNR on the dual energy subtracted image of a 6-cm, 50% glandular breast. Breast composition and thickness were found to have little influence on the optimized technique factors. We conclude that the simulation and phantom studies demonstrated the effectiveness of CEDEM using the prototype breast CT scanner in producing high-quality, lesion-enhanced images.
AB - Contrast-enhanced dual energy mammography (CEDEM) has been shown effective in enhancing the visibility of breast cancer in diagnostic mammographic images. The simulation and phantom studies of CEDEM were implemented to enhance acquisition techniques of a dedicated cone-beam breast CT scanner fabricated in our laboratory. CEDEM images were computer-simulated numerically, and the results were compared and validated with physical experiments using a custom-made breast-equivalent phantom with pseudo anatomical structures. The technique factors to be optimized included low- and high-energy x-ray spectra (kVp), spectra filters and mAs (x-ray tube current × scan time in second). Signal-difference-to-noise ratio (SDNR) of the log-weighted subtracted image was computed to optimize subtraction parameters using several combinations of breast compositions and thicknesses. Both simulation and phantom studies suggest that 40 kVp (filtered with 1.5 mm Al) and 50 kVp (filtered with 1.5 mm Al and 0.3 mm Cu) were the optimal spectra with the highest SDNR on the dual energy subtracted image of a 6-cm, 50% glandular breast. Breast composition and thickness were found to have little influence on the optimized technique factors. We conclude that the simulation and phantom studies demonstrated the effectiveness of CEDEM using the prototype breast CT scanner in producing high-quality, lesion-enhanced images.
KW - Anatomical breast phantom
KW - Computer simula-tion
KW - Contrast-enhanced dual energy mammography
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U2 - 10.1007/978-3-540-70538-3_18
DO - 10.1007/978-3-540-70538-3_18
M3 - Conference contribution
AN - SCOPUS:50949098877
SN - 3540705376
SN - 9783540705376
T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
SP - 124
EP - 129
BT - Digital Mammography - 9th International Workshop, IWDM 2008, Proceedings
T2 - 9th International Workshop on Digital Mammography, IWDM 2008
Y2 - 20 July 2008 through 23 July 2008
ER -