Simultaneous analysis of tumor and stromal gene expression profiles from xenograft models

Elizabeth Iorns; Jennifer Clarke; Toby Ward; Sonja Dean; Marc Lippman

doi:10.1007/s10549-011-1784-8

Simultaneous analysis of tumor and stromal gene expression profiles from xenograft models

Elizabeth Iorns, Jennifer Clarke, Toby Ward, Sonja Dean, Marc Lippman

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Identifying the gene expression alterations that occur in both the tumor and stroma is essential to understanding tumor biology. We have developed a dual-species microarray analysis method that allows the dissection of both tumor and stromal gene expression profiles from xenograft models, based on limited interspecies cross-hybridization on Illumina gene expression beadchips. This methodology allows for simultaneous genome-wide analysis of gene expression profiles of both tumor cells and the associated stromal tissue.

Original language	English (US)
Pages (from-to)	321-324
Number of pages	4
Journal	Breast Cancer Research and Treatment
Volume	131
Issue number	1
DOIs	https://doi.org/10.1007/s10549-011-1784-8
State	Published - Jan 2012
Externally published	Yes

Keywords

Cross-hybridization
Dual-species
Gene expression profile
Microarray
Tumor microenvironment
Tumor stroma
Xenograft model

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1007/s10549-011-1784-8

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abstract = "Identifying the gene expression alterations that occur in both the tumor and stroma is essential to understanding tumor biology. We have developed a dual-species microarray analysis method that allows the dissection of both tumor and stromal gene expression profiles from xenograft models, based on limited interspecies cross-hybridization on Illumina gene expression beadchips. This methodology allows for simultaneous genome-wide analysis of gene expression profiles of both tumor cells and the associated stromal tissue.",

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AU - Clarke, Jennifer

AU - Ward, Toby

AU - Dean, Sonja

AU - Lippman, Marc

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N2 - Identifying the gene expression alterations that occur in both the tumor and stroma is essential to understanding tumor biology. We have developed a dual-species microarray analysis method that allows the dissection of both tumor and stromal gene expression profiles from xenograft models, based on limited interspecies cross-hybridization on Illumina gene expression beadchips. This methodology allows for simultaneous genome-wide analysis of gene expression profiles of both tumor cells and the associated stromal tissue.

AB - Identifying the gene expression alterations that occur in both the tumor and stroma is essential to understanding tumor biology. We have developed a dual-species microarray analysis method that allows the dissection of both tumor and stromal gene expression profiles from xenograft models, based on limited interspecies cross-hybridization on Illumina gene expression beadchips. This methodology allows for simultaneous genome-wide analysis of gene expression profiles of both tumor cells and the associated stromal tissue.

KW - Cross-hybridization

KW - Dual-species

KW - Gene expression profile

KW - Microarray

KW - Tumor microenvironment

KW - Tumor stroma

KW - Xenograft model

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Simultaneous analysis of tumor and stromal gene expression profiles from xenograft models

Abstract

Keywords

ASJC Scopus subject areas

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