OBJECTIVES: This study aimed to present 2 patients with simple partial refractory status epilepticus (RSE) treated with a single oral lacosamide (LCM) dose and to review the literature on this topic. METHOD: A retrospective description of 2 patients with simple partial RSE treated with 300 mg of LCM per os (PO) and a literature review were done. RESULTS: Both patients responded to single-dose oral LCM treatment with seizure cessation after 30 minutes. CONCLUSIONS: This is the first report on successful treatment of simple partial RSE with a single-dose of LCM PO. Oral LCM might represent an option for treatment of patients presenting with simple partial RSE.
- Focal status epilepticus
- Refractory status epilepticus
- Simple partial status epilepticus
ASJC Scopus subject areas
- Clinical Neurology
- Pharmacology (medical)