Single dose total lymphoid irradiation combined with cyclophosphamide as immunosuppression for human marrow transplantation in aplastic anemia

Tae H. Kim; John H. Kersey; Faiz M. Khan; Wilfred Sewchand; Norma Ramsey; William Krivit; Peter Coccia; Mark E. Nesbit; Seymour H. Levitt

doi:10.1016/0360-3016(79)90605-9

Single dose total lymphoid irradiation combined with cyclophosphamide as immunosuppression for human marrow transplantation in aplastic anemia

Tae H. Kim, John H. Kersey, Faiz M. Khan, Wilfred Sewchand, Norma Ramsey, William Krivit, Peter Coccia, Mark E. Nesbit, Seymour H. Levitt

Pediatrics Hematology/Oncology

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Six patients with aplastic anemia underwent bone marrow transplantation following conditioning with high dose cyclophosphamide and single dose total lymphoid irradiation with 750 rad, 26 rad/min at the midplane of the patient. They all received bone marrow from human leukocyte antigens/mixed lymphocyte culture (HLA/MLC) matched siblings. Five of 6 patients were alive without complications at 12, 11, 7, 4 and 4 months respectively. The remaining patient died from sepsis which he had prior to transplantation. There were no graft rejection, graft-vs-Host Disease (GVHD) or interstitial pneumonitis among these patients. The procedure was well tolerated with minimal side effects. The results will be compared with those of groups whose bone marrow was previously transplanted with different immunosuppressive methods.

Original language	English (US)
Pages (from-to)	993-996
Number of pages	4
Journal	International Journal of Radiation Oncology, Biology, Physics
Volume	5
Issue number	7
DOIs	https://doi.org/10.1016/0360-3016(79)90605-9
State	Published - Jul 1979

Keywords

Aplastic anemia
Bone marrow transplantation
Total lymphoid irradiation

ASJC Scopus subject areas

Radiation
Oncology
Radiology Nuclear Medicine and imaging
Cancer Research

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Kim, T. H., Kersey, J. H., Khan, F. M., Sewchand, W., Ramsey, N., Krivit, W., Coccia, P., Nesbit, M. E., & Levitt, S. H. (1979). Single dose total lymphoid irradiation combined with cyclophosphamide as immunosuppression for human marrow transplantation in aplastic anemia. International Journal of Radiation Oncology, Biology, Physics, 5(7), 993-996. https://doi.org/10.1016/0360-3016(79)90605-9

Kim, TH, Kersey, JH, Khan, FM, Sewchand, W, Ramsey, N, Krivit, W, Coccia, P, Nesbit, ME & Levitt, SH 1979, 'Single dose total lymphoid irradiation combined with cyclophosphamide as immunosuppression for human marrow transplantation in aplastic anemia', International Journal of Radiation Oncology, Biology, Physics, vol. 5, no. 7, pp. 993-996. https://doi.org/10.1016/0360-3016(79)90605-9

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abstract = "Six patients with aplastic anemia underwent bone marrow transplantation following conditioning with high dose cyclophosphamide and single dose total lymphoid irradiation with 750 rad, 26 rad/min at the midplane of the patient. They all received bone marrow from human leukocyte antigens/mixed lymphocyte culture (HLA/MLC) matched siblings. Five of 6 patients were alive without complications at 12, 11, 7, 4 and 4 months respectively. The remaining patient died from sepsis which he had prior to transplantation. There were no graft rejection, graft-vs-Host Disease (GVHD) or interstitial pneumonitis among these patients. The procedure was well tolerated with minimal side effects. The results will be compared with those of groups whose bone marrow was previously transplanted with different immunosuppressive methods.",

keywords = "Aplastic anemia, Bone marrow transplantation, Total lymphoid irradiation",

author = "Kim, {Tae H.} and Kersey, {John H.} and Khan, {Faiz M.} and Wilfred Sewchand and Norma Ramsey and William Krivit and Peter Coccia and Nesbit, {Mark E.} and Levitt, {Seymour H.}",

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AU - Kim, Tae H.

AU - Kersey, John H.

AU - Khan, Faiz M.

AU - Sewchand, Wilfred

AU - Ramsey, Norma

AU - Krivit, William

AU - Coccia, Peter

AU - Nesbit, Mark E.

AU - Levitt, Seymour H.

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AB - Six patients with aplastic anemia underwent bone marrow transplantation following conditioning with high dose cyclophosphamide and single dose total lymphoid irradiation with 750 rad, 26 rad/min at the midplane of the patient. They all received bone marrow from human leukocyte antigens/mixed lymphocyte culture (HLA/MLC) matched siblings. Five of 6 patients were alive without complications at 12, 11, 7, 4 and 4 months respectively. The remaining patient died from sepsis which he had prior to transplantation. There were no graft rejection, graft-vs-Host Disease (GVHD) or interstitial pneumonitis among these patients. The procedure was well tolerated with minimal side effects. The results will be compared with those of groups whose bone marrow was previously transplanted with different immunosuppressive methods.

KW - Aplastic anemia

KW - Bone marrow transplantation

KW - Total lymphoid irradiation

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Single dose total lymphoid irradiation combined with cyclophosphamide as immunosuppression for human marrow transplantation in aplastic anemia

Abstract

Keywords

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