Single molecule studies of DNA binding proteins using optical tweezers

Yuji Kimura, Piero R. Bianco

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations


Optical tweezers have become a versatile tool in the biological sciences. Combined with various types of optical microscopy, they are being successfully used to discover the fundamental mechanism of biological processes. Recently, the study of proteins acting on DNA was aggressively undertaken at the single-molecule level. Here, we review the most recent studies which have revealed the dynamic behavior of individual protein molecules at work on DNA, providing detailed mechanistic insight that could not be revealed, at least not easily, using bulk-phase or ensemble approaches.

Original languageEnglish (US)
Pages (from-to)868-874
Number of pages7
Issue number8
StatePublished - 2006
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Environmental Chemistry
  • Spectroscopy
  • Electrochemistry

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