A study of the sister chromatid exchange (SCE) frequency in peripheral lymphocytes from 26 human subjects, with in vivo age of the cels as the variable, demonstrated a significant increase in SCE frequency with increasing age of the subject (analysis of variance: p < 0.01). The cells were cultured in Eagle's basal medium with 5-bromodeoxyuridine added to a final concentration of 10 μM. These results are contradictive to the brunt of the literature which indicates that background SCE frequency does not change with age.
|Original language||English (US)|
|Number of pages||4|
|Journal||Mechanisms of Ageing and Development|
|State||Published - May 1981|
ASJC Scopus subject areas
- Developmental Biology