Sister chromatid exchange in aged human lymphocytes. A brief note

Michael A. Schmidt, Warren G. Sanger

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


A study of the sister chromatid exchange (SCE) frequency in peripheral lymphocytes from 26 human subjects, with in vivo age of the cels as the variable, demonstrated a significant increase in SCE frequency with increasing age of the subject (analysis of variance: p < 0.01). The cells were cultured in Eagle's basal medium with 5-bromodeoxyuridine added to a final concentration of 10 μM. These results are contradictive to the brunt of the literature which indicates that background SCE frequency does not change with age.

Original languageEnglish (US)
Pages (from-to)67-70
Number of pages4
JournalMechanisms of Ageing and Development
Issue number1
StatePublished - May 1981

ASJC Scopus subject areas

  • Aging
  • Developmental Biology


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