TY - JOUR
T1 - Sister-chromatid exchanges and chromosomal aberrations in rats treated with phenacetin, phenazone and caffeine
AU - Granberg-Öhman, Ingrid
AU - Johansson, S.
AU - Hjerpe, A.
N1 - Funding Information:
Supported by grant 126-B80-O9X from the Swedish Cancer Society.
PY - 1980
Y1 - 1980
N2 - To study chromosomal aberrations and the frequency of sister-chromatid exchanges (SCE) a long-term chronic toxicity study was performed in rats treated with phenacetin, phenazone and caffeine, alone and in different combinations. Compared with controls, aberrations such as gaps, breaks and structural dearrangements were only increased in the group treated by phenacetin alone. After mitomycin C treatment of the blood culture, the aberrations were markedly, but not significantly, increased. All experimental groups showed a higher SCE frequency, most deviating in the rats treated with phenacetin alone. This correlates with the fact that phenacetin is a strong general carcinogen.
AB - To study chromosomal aberrations and the frequency of sister-chromatid exchanges (SCE) a long-term chronic toxicity study was performed in rats treated with phenacetin, phenazone and caffeine, alone and in different combinations. Compared with controls, aberrations such as gaps, breaks and structural dearrangements were only increased in the group treated by phenacetin alone. After mitomycin C treatment of the blood culture, the aberrations were markedly, but not significantly, increased. All experimental groups showed a higher SCE frequency, most deviating in the rats treated with phenacetin alone. This correlates with the fact that phenacetin is a strong general carcinogen.
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U2 - 10.1016/0165-1218(80)90143-3
DO - 10.1016/0165-1218(80)90143-3
M3 - Article
C2 - 6448957
AN - SCOPUS:0018818529
VL - 79
SP - 13
EP - 18
JO - Mutation Research - Genetic Toxicology Testing and Biomonitoring of Environmental or Occupational Exposure
JF - Mutation Research - Genetic Toxicology Testing and Biomonitoring of Environmental or Occupational Exposure
SN - 0165-1218
IS - 1
ER -