Abstract
(Chemical Equation Presented) Location, location, location: A new chemoselective method to site- and degree-specifically install lysine analogues into recombinant proteins provides facile access to near-homogeneously methylated and acetylated histone analogues (see scheme; R1, R 2, R3 = H, Me, acetyl), which can be used to study the impact of histone modification on chromatin structure and function.
Original language | English (US) |
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Pages (from-to) | 6399-6401 |
Number of pages | 3 |
Journal | Angewandte Chemie - International Edition |
Volume | 47 |
Issue number | 34 |
DOIs | |
State | Published - Aug 11 2008 |
Externally published | Yes |
Keywords
- Dehydroalanine
- Histones
- Lysine derivatives
- Protein modifications
ASJC Scopus subject areas
- Catalysis
- General Chemistry